It is the first time described in vivo (in animals) oncogenic factor SOX11 protein, a transcription factor involved in the development and aggressiveness of lymphoma mantle cell, one of the most aggressive non-Hodkings lymphomas are. Because it is very difficult to treat, the research community is particularly interested in identifying therapeutic targets to address a disease whose survival does not exceed 3-5 years. This is the case of Dr. Virginia Amador, researcher in the area of human and experimental functional oncomorphology IDIBAPS, submitted last February 6 the results of their research work focused on the molecule SOX11. Under the title of the seminar Functional analysis of SOX11 in mantle cell lymphoma, Virginia showed that overexpression of the transcription factor SOX11 not only promotes the creation and progression of mantle cell lymphoma, but is also involved in the aggressiveness of it. This makes it the perfect therapeutic target to inhibit cancer development. The results are published by the journal Blood.“We discovered that SOX11 activates two ways: on one hand, inhibits the differentiation of lymphoma cells blocking them mantle in a state of naive cells, and secondly, stimulates angiogenesis through PDGFA, a molecule that plays a fundamental role in tumor growth“, says Amador. “If we block the two pathways we could inhibit the development of breast cancer“. The next step is to test the ability of these inhibitors to block the effect of oncogenic human SOX11.

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