Extensive research in tissue engineering, wound healing and photoageing in recent decades revealed the important role Growth Factors may play in reversing the effects of skin aging. They have been described to accelerate the process of re-epithelialization and skin repair, to stimulate the regeneration of the Extra Cellular Matrix, to boost collagen synthesis and to promote and restore an impaired immune response, among others.

MULTIEFFECT 3R (SH GM-CSF) and MULTIEFFECT R+D (SH HGH), showed both excellent performance in skin cell lines, in anti-age, regeneration and whitening activities

TGF beta2 showed a strong stimulation of the expression of extracellular matrix (EMC) proteins, like collagen, mediated by the SMAD pathway activationnd, and fibronectin, .

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