'Live' breast cancer biobank to accelerate more precise testing of experimental anti-cancer medicines

by Vall d’Hebron

8 years ago
breast cancer, anti-cancer therapies, biobank

High-throughput mass screening platform to spur drug development in breast cancer by testing response to over 100 anti-cancer agents as monotherapy or in combination. Response to therapy validated in ...

Therapeutic RANK inhibition reduces breast cancer recurrence

by IBEC - Institut de Bioenginyeria de Catalunya

8 years ago
breast cancer, pathway RANK / RANKL, metastases

Researchers at the Institute of Biomedical Research of Bellvitge (IDIBELL), led by Dr. Eva Gonzalez-Suarez, have shown that pharmacological and genetic inhibition of signaling pathway RANK / RANKL lea...

Exploring mechanisms of resistance against ER+ and BRCA1 breast cancer therapies

by Vall d’Hebron

8 years ago
cáncer de mama, BRCA1, CDK4/6, PI3K, ER+, breast cancer

Various research lines led by VHIO aim at better deciphering how tumor cells acquire resistance to anticancer agents including palbociclib and treatments inducing DNA damage. The expression of partial...

The importance of keeping silent... in breast cancer cells

by Centre for Genomic Regulation

8 years ago
gene-silencing mechanisms, breast cancer

Researchers at the Centre for Genomic Regulation describe a repression mechanism active in hormone-dependent breast cancer cells for the first time. The repression complex of these cells silences gene...

First molecular test that enables fine-tuned prognosis and prediction in advanced breast cancer

by Fundació Clínic per a la Recerca Biomèdica

8 years ago
breast cancer, prognosis, genomic test

Findings show that the genomic classification of tumors — the molecular subtyping of primary tumors, can predict the evolution of patients from the onset of metastasis and that this cancer intrinsic...

Researchers discover that breast cancer tumour growth is dependent on lipid availability

by IRB Barcelona - Instituto de Investigación Biomédica

8 years ago
breast cancer, lipid, LIPG

In an article published in Nature Communications, scientists at IRB Barcelona reveal that breast cancer cells require fatty acids from the extracellular environment in order to continue proliferating....

Myriad myRisk® Hereditary Cancer: expanding genetic testing for breast cancer patients

by Myriad Genetics Iberia

8 years ago
breast cancer, cancer genes, BRCA1/2

Prospective Clinical Study Showed the myRisk Test Identified 70 Percent More Deleterious Mutations than BRCA Testing Alone with 42 Percent of These in Women Over Age 45.

A genetic test at the time of diagnosis, useful for predicting treatment response in breast cancer

by Fundació Clínic per a la Recerca Biomèdica

8 years ago
breast cancer, genomic test, chemotherapy

Researchers have shown that the biology identified with genomic data is the most significant predictor of treatment response and survival beyond the 4-5 variables that are currently used in clinical p...

Quantification of therapeutic targets by mass spectrometry

by Vall d’Hebron

9 years ago
breast cancer, mass spectrometry, proteins

Research at VHIO has for the first time evidenced the clinical utility of mass spectrometry in formalin-fixed, paraffin-embedded breast cancer tissue samples. VHIO researchers have shown the quantific...

IRB Barcelona identifies the gene responsible for metastasis of breast cancer to the bone

by IRB Barcelona - Instituto de Investigación Biomédica

9 years ago
metastasis, breast cancer, bones, Inbiomotion

A study published in the Journal of National Cancer Institute (JNCI) by ICREA researcher Roger Gomis may be key to the early detection of patients at risk of developing metastasis to the bone. This ne...

Quality standards of breast cancer services differ across Europe

by European Commission - Joint Research Centre

9 years ago
breast cancer

Most European countries acknowledge the importance of quality in breast cancer services but use different standards to cover the various stages of care