Combination of fasting and chemotherapy may improve cancer response, with different effects according to sex

by CNIO - Centro Nacional de Investigaciones Oncológicas

2 days ago
fasting, chemotherapy

New study reveals that the positive effect of combining fasting and chemotherapy in a controlled manner is more pronounced in males than in females. The result shows the importance of considering sex ...

Immunotherapy with genetically modified immune cells increases survival of patients with aggressive B lymphoma who do not respond to chemotherapy

by Hospital Universitari de Bellvitge

2 years ago
genetically modified, immune cells, aggressive B lymphoma, chemotherapy, CART cells

The use of genetically modified T lymphocytes (CART lymphocytes) to recognize cancer cells increases the life expectancy of patients with chemotherapy-resistant lymphoma.

A new approach to metastatic melanoma discovered

by IMIM - Institut Hospital del Mar d'Investigacions Mèdiques

3 years ago
BRAF oncogene inhibitors, chemotherapy, Cancer, metastatic melanoma, skin cancer

Combining chemotherapy and BRAF oncogene inhibitors is a very effective strategy for fighting metastatic melanoma, the leading cause of death from skin cancer in the world.

A protein that facilitates DNA repair may potentiate chemotherapy

by CNIO - Centro Nacional de Investigaciones Oncológicas

3 years ago
PrimPol protein, chemotherapy, tumour cells, cancer treatments

The PrimPol protein helps the cell to survive the damage caused by chemotherapy The researchers want to make tumour cells more sensitive to cancer treatments by repressing PrimPol

MEET A HERO: Grant, 2 year old at diagnosis

by Oncoheroes Biosciences

3 years ago
childhood cancer, cancer foundation, chemotherapy

"Upside down," said Grant looking at himself in the mirror and pointing at his Spiderman T-shirt while standing up on a hospital bed. Grant Gossling was 2 years old when he was diagnosed with high-ris...

Identified the cellular process by which Cisplatin chemotherapy causes neuronal damage

by Hospital Universitari de Bellvitge

4 years ago
cancer, chemotherapy, Cisplatin, neuropathy, peripheral nervous system

Once the mechanism has been described by a team from IDIBELL, ICO, HUB, and UAB, new strategies can be designed to alleviate the adverse effects of Cisplatin, one of the most common drugs in chemoth...

An international clinical trial extends the effectiveness of immunotherapy to more lung cancer patients

by CNIO - Centro Nacional de Investigaciones Oncológicas

5 years ago
immunotherapy, chemotherapy, squamous cell carcinoma, metastasis, lung cancer

Combining immunotherapy with chemotherapy in patients with metastatic squamous cell carcinoma "significantly increases" the survival of patients, write the authors in The New England Journal of Medici...

Hospital Clínic will implement a new genomic test to predict response to treatment in breast cancer

by Fundació Clínic per a la Recerca Biomèdica

7 years ago
genomic test, chemotherapy, breast cancer, third generation test, test PAM50

Researchers from Hospital Clínic and IDIBAPS lead an international study in which they have developed a genomic test to predict the response to chemotherapy in breast cancer. Hospital Clínic of Barc...

Scientists discover a cause of multiple resistance to cancer chemotherapy

by IBEC - Institut de Bioenginyeria de Catalunya

8 years ago
cancer, Chemotherapy

The introduction of cancer chemotherapy was a revolution for the treatment of this disease in those cases in which the cure is no longer possible only with the mere extirpation of the tumor. Chemother...

The absence of a protein points out the prognosis of liver cancer patients

by CIMA - Centro de Investigación Médica Aplicada

8 years ago
proteomics, MTAP protein, chemotherapy, resistance, liver cancer

Using proteome technology, CIMA researchers have established the mechanisms that favor tumor growth and resistance to chemotherapy

CNIO scientists discover a new mechanism of resistance to chemotherapy

by CNIO - Centro Nacional de Investigaciones Oncológicas

8 years ago
cancer, chemotherapy, CRISPR, ATR kinase, CDC25A

Óscar Fernández-Capetillo’s team reports that ATR kinase inhibitors are more effective in cells with high levels of CDC25A protein expression. ATR inhibitors were previously developed at the CNIO ...

The detection of a genetic alteration in blood samples predicts resistance to treatment in metastatic prostate cancer

by Fundació Clínic per a la Recerca Biomèdica

8 years ago
TMPRSS2-ERG, prostate cancer, taxanes, chemotherapy

The detection of TMPRSS2-ERG in the blood of patients with resistant metastatic prostate cancer predicts resistance to taxanes, such as docetaxel, and may be useful for selecting the best treatment op...