Identified an early neuronal dysfunction in Parkinson’s that could help early diagnosis

by Hospital Universitari de Bellvitge

3 years ago
neurodegenerative disease, neuronal death

Parkinson’s is a neurodegenerative disease characterized by the death of dopaminergic neurons. This neuronal death leads to a series of motor manifestations characteristic of the disease, such as tr...

A clinical trial with calcitriol has begun to validate its therapeutic potential for treating Friedreich's Ataxia

by IRB Lleida. Institut de Recerca Biomèdica

3 years ago
Friedreich's ataxia, neurodegenerative disease, clinical trial

Friedreich's ataxia is a minority neurodegenerative disease characterised by difficulty in coordinating movements

The French Association of Ataxia in Friedreich renews its 25,000 euro grant to validate the therapeutic potential of calcitriol for treating this rare malaltia

by IRB Lleida. Institut de Recerca Biomèdica

4 years ago
neurodegenerative disease, diabetes, Ataxia in Friedreich, calcitriol, rare malaltia, vitamin D

The Biochemical Research Group of Oxidative Stress leads the project

New brain cell models to evaluate therapy on neurodegenerative disease Sanfilippo C

by Universitat de Barcelona

4 years ago
neurodegenerative disease, cells, Sanfilippo syndrome

The Sanfilippo syndrome type C is a severe neurodegenerative disease which appearws during the first years of life and for which there is no treatment yet. A recent study, published in Journal of Clin...

New aspects of Globular Glial Tauopathy could help in the design of more effective drugs against this dementia

by Hospital Universitari de Bellvitge

4 years ago
Tau, neurodegenerative disease, glial cells, protein, dementia

Tau is not the only protein implicated in protein inclusion formation responsible for this neurodegenerative disease.

Reelin reverts the main pathological processes related to Alzheimer’s and other tauopathy

by Universitat de Barcelona

4 years ago
neuronal migration, synaptic plasticity, Alzheimer’s, Neurobiology, neurodegenerative disease, brain plasticity, tauopathy

Promoting the signalling pathway of reelin –an essential extracellular protein for the neuronal migration and synaptic plasticity- could be an effective therapeutical strategy to counterbalance t...

Minoryx Therapeutics receives FDA Orphan Drug Designation for leriglitazone in Friedreich’s Ataxia

by Minoryx Therapeutics

4 years ago
neurodegenerative disease, Friedreich’s Ataxia, FDA, drug

Leriglitazone (MIN-102) is a novel, brain penetrant, orally bioavailable and selective PPARγ agonist Second Orphan Drug Designation granted by the FDA for leriglitazone in addition to X-linked adr...

Researchers perform thousands of mutations to understand amyotrophic lateral sclerosis

by IBEC - Institut de Bioenginyeria de Catalunya

5 years ago
amyotrophic lateral sclerosis, ALS, neurodegenerative disease, mutations

Researchers from IBEC and CRG in Barcelona use a technique called high-throughput mutagenesis to study Amyotrophic Lateral Sclerosis (ALS), with unexpected results.