Lleida study demonstrates the protective effect of a protein to reduce the progression of fibrosis of the kidneys

by IRB Lleida. Institut de Recerca Biomèdica

4 years ago
kidney disease, protein, transplant

It's a new strategy for treating kidney disease and avoiding dialysis or transplantation

DGK ζ is key for actin cytoskeleton remodelling at the B cell immune synapse

by Centro Nacional de Biotecnología (CNB)

4 years ago
protein, cytoskeleton, immune

DGK (diacylglycerol kinases) are proteins known for their role as negative regulators of the immune response of B and T lymphocytes. For this reason, they are under study as therapeutic targets for th...

Discovered a small protein that synchronizes the circadian clocks in shoots and roots

by CRAG

4 years ago
shoots, roots, circadian clocks, protein

The CSIC researcher Paloma Mas leads a study published in Nature Plants demonstrating that the clock protein ELF4 moves in synch with temperature to coordinate rhythms in shoots and roots.

DRUG TARGETS: The heat shock protein 90 inhibitor ganetespib failed to improve outcomes when added to chemotherapy in advance NSCLC (phase III GALAXY-2 trial). Samples were obtained for biomarker studies; results not yet reported

by OncoDNA

4 years ago
protein, cancer, lung

Randomized Phase III Study of Ganetespib, a Heat Shock Protein 90 Inhibitor, With Docetaxel Versus Docetaxel in Advanced Non–Small-Cell Lung Cancer (GALAXY-2)

Experts in G protein-coupled receptors meet at the UB to discuss new pharmacological perspectives

by Hospital Universitari de Bellvitge

4 years ago
protein, pharmaco, Parkinson, schizophrenia

Within the framework of the X Esteve Foundation Discussion Group, on February 13th and 14th the tenth meeting of the working group on new advances in the field of G-protein coupled receptors (GPCR) wa...

Identifican el mecanismo que desencadena un tipo raro de distrofia muscular

by Universitat Autònoma de Barcelona (UAB)

4 years ago
molecular mechanism, protein, genetic mutations, rare disease, muscular dystrophy, amyloid fibrils

A study led by the IBB-UAB has identified the molecular mechanism through which a protein, when carrying genetic mutations associated with a rare disease known as limb-girdle muscular dystrophy, type ...

New aspects of Globular Glial Tauopathy could help in the design of more effective drugs against this dementia

by Hospital Universitari de Bellvitge

4 years ago
Tau, neurodegenerative disease, glial cells, protein, dementia

Tau is not the only protein implicated in protein inclusion formation responsible for this neurodegenerative disease.

Key Protein Identified in Cardiac Scarring and Reshaping After Pressure Overload

by Hospital de la Santa Creu i Sant Pau

4 years ago
protein, reshaping, cardio, pressure

Researchers at IRB Barcelona study how altered protein degradation contributes to the development of tumours

by IRB Barcelona - Instituto de Investigación Biomédica

4 years ago
protein, cancer, degradation

Published in the journal Nature Cancer, the study analyses how genetic alterations in tumour cells prevent the correct degradation of the proteins involved in tumour development and growth, thereby le...

Researchers describe a key protein for Epstein-Barr virus infection, which causes mononucleosis and cancer

by IRB Barcelona - Instituto de Investigación Biomédica

5 years ago
protein, infection, mononucleosis, cancer

Two studies by IRB Barcelona and IBMB-CSIC published in Nature Communications reveal the portal structure of the Epstein-Barr virus and bacteriophage T7. No treatment is currently available for the...

OncoDNA, a pioneering study demonstrates an impact of molecular profiling on the evolution of cancer

by OncoDNA

5 years ago
cancer, DNA, protein, biomarker

OncoDNA, a company which specialises in precision medicine for the treatment and diagnosis of cancer, has participated in a pioneering study on the usefulness and impact of molecular profiling in canc...

IrsiCaixa develops antibodies that block one of the internalization pathways of the Ebola virus into human cells

by IrsiCaixa

5 years ago
Ebola, HIV, develops novel antibodies, myeloid cells, protein, serious haemorrhagic disease, vaccines

The study demonstrates that the receptor Siglec-1 is used by different virus, such as Ebola, Marburg and HIV, to enter the myeloid cells and develops novel antibodies against this protein.