Bioingenium is a service company CDMO (Contract Development & Manufacturing Organization) offering Process Development & Custom Manufacturing Services for most types of biologics, covering from early stages of development (Proof-of-concept & Pre-clinical) until industrial scale manufacturing.
With a large experience in upstream and downstream processes, we offer flexible and scalable equipment for producing and purifying therapeutic proteins.
Bioingenium has a proprietary technology for heterologous Protein expression in Pichia pastoris and Bacteria.
We have the knowhow and capabilities to produce your protein of interest from small scale to pilot plant scale, we can develop your production process make it robust and affordable.
Our services include:
- Strain development.
- Production of mg quantities for proof-of-concept in bacteria, Pichia pastoris, CHO and HEK cells.
- Fermentation/cell culture process development.
- Purification process development.
- Formulation of proteins.
- Process scale-up.
- Development of analytical tools.
Recombinant Protein Production Services
In Bioingenium we are experts in the production of recombinant proteins using different expression systems, from bacterial to mammalian cell line expression. We have many years of expertise producing and purifying difficult proteins for many different applications. Our compromise is to fulfill the customer expectations in terms of quantity and also quality of the product.
Bioingenium has developed expressions systems for E. coli and P. pastoris with freedom to operate, so our clients do not have to pay any fees or royalties to third companies. Our aim is to provide the customer with a full service that includes cloning, strain selection, analytics development, upstream development, downstream development and protein characterization.
Expression in P. pastoris
In many cases expression in E. coli could be not adequate for your protein of interests. Pichia pastoris is a good choice for proteins containing di-sulfide bridges, secreted proteins or complex proteins. Our system is able to introduce several genes into the expression strains leaving a wild type genotype without any gene for antibiotics resistance. We are recognized experts in P. pastoris with more than 20 publications in the field.
Expression in E. coli
Our vectors for expression in E. coli allow the production of g per liter quantities of protein. We have a variety of vectors that provides the capacity to use different promoters and chaperones to achieve the highest productivity.
Expression in CHO and HEK
We can provide you with transient expression of your target protein with CHO or HEK cells. High quality and quantity of recombinant proteins can be achieved from cultivation of mammalian cells and a human glycosylation profile is obtained.
Process development
A wide range of services at your disposal: Bioingenium develops an efficient production process for your recombinant proteins
Viability studies are a key point for the success of therapeutic recombinant proteins. A good bioprocess is critical since small errors could be amplified throughout the complete product development. For that reason at Bioingenium we use our experience to select the best expression system for each of the projects in which we are involved. Our processes are thought to be easily scalable to industrial scale and based on biological, technical and economical criteria.
We can cover all the developing steps in the process of production of a recombinant protein from gene design and cloning up to development of the upstream, downstream processes and scale up.
Pichia pastoris freedom to operate system
Features:
Our customers are biotech companies and pharma companies looking for a small production batch of proteins for proof of concept studies and also companies that are in the process development of the validated product.
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