Innovative technology for thyroid cancer screening

IDIBAPS participates in the EU-funded project LUCA (Laser and Ultrasound Co-analyzer for Thyroid Nodules) that aims to develop a new, low-cost technology for the screening of thyroid cancer. The novel device will provide doctors with enhanced information required to provide better and more specific results in thyroid nodule screening and enable better diagnosis.

Thyroid cancer is a major and growing health challenge with around three hundred thousand new cases diagnosed worldwide annually. Current methods do not provide sufficient support to surgeons in their decision on the appropriate course of action, which leads to significant number of unnecessary surgeries and a reduced quality of life for patients. This calls for an increased sensitivity and specificity of the conventionally applied screening process.

“The novel device combines ultrasound and near-infrared diffuse optical technologies in a single device and a probe. By combining information about tissue hemodynamics, chemical constitution as well as anatomy, it will overcome the shortcomings of present techniques while screening for malign thyroid nodules. If successful, this will save millions of euros over the coming decades and improve the lives of millions of Europeans”, says Prof. Turgut Durduran from ICFO-TheInstitute of Photonic Sciences (Castelldefels, Spain), Scientific Coordinator of LUCA.

A multidisciplinary team made up of eight partners including clinical endocrinologists, radiologists, physicists, engineers and industry players will carry out this ambitious research project. Phase 1 of the project will be focused on the development and construction of device components, while phase 2 will see the implementation and clinical validation of the LUCA demonstrator.

“A new tool made concomitantly with thyroid ultrasound may provide additional information to help us distinguish between benign and malignant nodules. This would allow a reduction in the number of surgeries for these reasons andwould have an important socio-economic impact, diminishing the number of surgeries and the associated comorbidities, as well as improving the quality of life of the patients affected”, comments Dr. Mireia Mora from the August Pi iSunyer Biomedical Research Institute (IDIBAPS) in Barcelona, Spain, which will be responsible for the clinical application of the tool, under the direction of Prof. Ramon Gomis.

The LUCA device has the potential to represent a very innovative tool for other types of cancer diagnosis, screening and therapy monitoring in areas of the body accessible to both techniques. Therefore, LUCA is expected to have a significant impact not onlyin the field of thyroid cancer but also in additional areas of cancer screening.

Background

The LUCA project started on February 1st, 2016 and, for a 4-year period, brings together recognized organisations and industry partners from all over Europe: ICFO –The Institute for Photonic Sciences, ES (Scientific Coordinator); Politecnico di Milano, IT; August PI iSunyer Biomedical Research Institute (IDIBAPS), ES; Hemophotonics SL, ES; Vermon SA, FR; ECM – Echo Control Medical, FR; University of Birmingham, UK; European Institute for Biomedical Imaging Research, AT.

The LUCA project receives funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 688303 and is an initiative of the Photonics Public Private Partnership (www.photonics21.org).