The Physics of Interfaces and Colloidal Systems research group at the Biosanitary Research Institute of Granada (ibs.GRANADA) has developed a protocol that improves knowledge about natural bone biomineralization, which may represent an advance to replace damaged bone tissue.
Bone tissue is made up of aligned collagen fibers that contain apatite crystals. These crystals are a fundamental element for the body to carry out regenerative functions in the bones, the so-called bone mineralization, where the collagen fibers are capable of controlling the growth of apatite crystals in a very limited range of collagen density, both being processes, the formation of collagen fibrils and mineralization, simultaneous.
The work of this group of researchers from ibs.GRANADA and the University of Granada is the design in the laboratory of soft and deformable materials based on so-called biomimetic peptides, which are short chains of amino acids that allow imitation of natural peptides and have turned out to be excellent templates for the growth of inorganic minerals, which try to emulate the biomineralization processes that occur in the bone tissue of the organism, being of special interest in this research the development of one of support materials capable of guiding bone regeneration.
In this ibs.GRANADA study, a protocol has been developed in which the self-assembly of the artificial peptide Fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF) is produced, at the same time as the formation of apatite crystals is carried out, creating a material of interest in tissue regeneration. This protocol much more reliably reproduces natural bone biogenesis in which both self-assembly of collagen fibrils and mineralization occur.
The resulting system allows expanding knowledge about bone biomineralization, which is of radical importance to improve medical treatment and promote the development of synthetic materials that are capable of replacing damaged bone tissue.
About the research group
The ibs.GRANADA Interphase Physics and Colloidal Systems research group, led by Modesto López, is a team that develops a wide range of interdisciplinary activities always based on an approach from the point of view of Materials Science and Technology, with a large number of national and international collaborators. More specifically, the research topics of the last five years are related to the preparation and mechanical characterization of biomaterials for tissue engineering, the mechanical properties of smart biomaterials, the preparation and characterization of drug carriers, and the use of nanoparticles for hyperthermia and controlled drug release.
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