Unfavorable environmental and developmental conditions may cause disturbances in protein folding in the endoplasmic reticulum (ER) that are recognized and counteracted by components of the Unfolded Protein Response (UPR) signaling pathways. The early cellular responses include transcriptional changes to increase the folding and processing capacity of the ER.
In this study, a collection of inducible transgenic Arabidopsis plants expressing a library of transcription factors was systematically screened for resistance toward UPR-inducing chemicals. 23 candidate genes that may function as novel regulators of the UPR were identified and of which only three genes were previously associated with the UPR.
In particular, WRKY75 is a genuine regulator of the ER-stress cellular responses as its expression was found to be directly responding to ER stress-inducing chemicals. In addition, transgenic Arabidopsis plants expressing WRKY75 showed resistance toward salt stress, connecting abiotic and ER-stress responses.
Original Paper:
Hossain, A; Henríquez-Valencia, C; Gómez-Páez, M; Medina, J; Orellana, A; Vicente-Carbajosa, J; Zouhar, J. 2016. "Identification of novel components of the Unfolded Protein Response in Arabidopsis". Frontiers in Plant Science. DOI: 10.3389/fpls.2016.00650".
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