Aging speeds up and lifetime becomes shorter in animals whose cells ‘believe’ to have too many nutrients, despite following a normal diet

by CNIO - Centro Nacional de Investigaciones Oncológicas

4 months ago
mTOR

A new paper finds now in animal models that when mTOR activity is just slightly increased, ageing set earlier on, and the lifetime of animals can be shortened by up to 20%.

CNIO researchers help to decipher the structure of the large molecular machine that assembles and activates mTOR

by CNIO - Centro Nacional de Investigaciones Oncológicas

3 years ago
mTOR, large macromolecular, nutrition, cancer, proteins

The mTOR protein assembles as part of a large macromolecular complex involved in cancer and nutrition, ageing and other essential processes in the body

An IDIBELL and UB research team demonstrates the involvement of glucose in the growth of tumor cells

by Hospital Universitari de Bellvitge

5 years ago
IDIBELL, UB, glucose, cancer, enzymes, mTOR

Researchers has demonstrated how is it connected molecularly the availability of nutrients and oncogenic signals

Alejo Efeyan joins the CNIO to study the relationship between metabolism and cancer

by CNIO - Centro Nacional de Investigaciones Oncológicas

9 years ago
mTOR, metabolism, cancer

Now, at the CNIO, Efeyan will lead the Metabolism and Cell Signalling Group to push the boundaries a little further: “We need to provide medical significance and a specific use: study these cell com...

Oncogene regulated by nutrients identified

by CNIO - Centro Nacional de Investigaciones Oncológicas

10 years ago
colorectal cancer, MCRS1 protein, mTOR

MCRS1 protein, in response to an excess of nutrients, induces an increase in the activity of mTOR (the mamm alian/mechanistic Target of Rapamycin); a protein that is altered in human diseases such as ...