A study carried out by researchers from the Biosanitary Research Institute of Granada (ibs.GRANADA) has revealed possible associations between human exposure to phthalates and the levels of inflammatory markers in the body, some of them related to diseases such as diabetes or cancer. The results, published in the journal Environmental Research, revealed associations between exposure to certain types of phthalates and different inflammatory proteins. These phthalates were used to increase the flexibility and durability of plastics, which are found in a wide variety of consumer products, such as plastic toys, food packaging, medical devices and construction materials.
This study was carried out by researchers from the groups E14-Preventive Medicine and Public Health y A15-Basic and Clinical Oncology from ibs.GRANADA, the University of Granada, CIBERESP and the San Cecilio, Santa Ana and Copenhagen-Rigshospitalet University Hospitals of Denmark, and blood samples from 213 people were analyzed, where associations between the concentrations of 10 metabolites of phthalates and 19 cytokines and acute phase proteins.
Dr. Juan Pedro Arrebola, researcher of the E14- Preventive Medicine and Public Health group at ibs.GRANADA and leader of the study, commented: “These results are of great relevance when identifying possible damages related to constant exposure to these compounds. , which could precede the long-term development of highly prevalent chronic diseases.”
This study is part of the GraMo cohort, with participants recruited in two hospitals: Hospital Universitario Clínico San Cecilio de Granada and Hospital Santa Ana de Motril. More research is currently being conducted in the GraMo study into the potential health implications of exposure to phthalates, along with other families of environmental chemical pollutants.
The results also highlight the need to limit the use of plastics as much as possible, and offer a significant contribution to the emerging field of immunoepidemiology and toxicology, opening new lines of research on environmental exposure and its impact on health. Human health.
About the groups
The research group E14-Preventive Medicine and Public Health ibs.GRANADA is made up of a multidisciplinary team of researchers specialized in epidemiology and statistics applied to health sciences. Its work focuses on addressing the main public health problems in the Spanish population, such as cancer, cardiovascular and metabolic diseases, as well as the epidemiology of traffic injuries. His research, oriented towards prevention and health promotion, seeks to understand the epidemiology of these health problems and associated factors, while also offering methodological support in the design and analysis of data to other clinical groups at ibs.GRANADA, the University of Granada and other institutions, with the aim of contributing to the advancement of scientific knowledge and improving the quality of life of the population.
More information about the group https://www.ibsgranada.es/grupos-de-investigacion/e14-medicina-preventiva-y-salud-publica/
El grupo A15-Basic and Clinical Oncology ibs.GRANADA is a multidisciplinary collaboration that brings together clinicians, physiotherapists, biologists, chemists and environmentalists with the aim of investigating the environmental causes of common diseases and addressing the diagnosis and treatment of tumor diseases. Its participation in the CIBER of Epidemiology and Public Health, the Childhood and Environment Network (INMA), the European network for Biomonitoring of Environmental Exposure (HBM4EU), the Biobank Platform, as well as collaboration in studies such as MCC-Spain, EPIC -Spain and the ibs.GRANADA Excellence Project define their objectives and work areas.
More information about the group https://www.ibsgranada.es/grupos-de-investigacion/a15-oncologia-basica-y-clinica/
Bibliographic reference: Requena, P., Pérez-Díaz, C., Mustieles, V., Peinado, FM, León, J., Pérez-Carrascosa, FM, Frederiksen, H., Salcedo-Bellido, I., Barrios-Rodríguez, R. , & Arrebola, JP (2023). Associations of circulating levels of phthalate metabolites with cytokines and acute phase reactants in a Spanish human cohort. Environmental Research (Vol. 216, p. 114470). Elsevier BV. https://doi.org/10.1016/j.envres.2022.114470
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