Remote uncontrol of DNA in cancer: genome 'wormholes'

by IBEC - Institut de Bioenginyeria de Catalunya

10 years ago
distant regulatory regions of genes, cancer

"We found that a class of distant regulatory regions of genes, called Super-Enhancers, presents changes in the levels of DNA methylation, the most important chemical signature of our genome." -says Dr...

IRB Barcelona: Meet Our Scientists - Roger Gomis: 'Light and credibility'

by IRB Barcelona - Instituto de Investigación Biomédica

10 years ago
IRB Barcelona, Roger Gomis, metastasis, cancer

IRB Barcelona group leader in the Oncology Programme talks about metastasis, challenges and Barcelona

CNIO scientists use the Internet network theory to decipher the first epigenetic communication network

by CNIO - Centro Nacional de Investigaciones Oncológicas

10 years ago
Internet network theory, epigenetics, DNA, stem cells, cancer

The scientists employed the algorithms used to analyse the influence and popularity of websites, such as Wikipedia or social networks. These results provide the basis for exploring communication betwe...

Participa el desarrollo embrionario en el riesgo a sufrir cáncer?

by UPF - Universitat Pompeu Fabra

10 years ago
cáncer, genómica, desarrollo embrionario

El estudio de la heterogeneidad de los genomas tumorales supone uno de los mayores retos a la hora de comprender el desarrollo y la progresión tumorales y su resistencia al tratamiento. Los autores d...

C. elegans as a model to study cancer, in Genetics and Nature Medicine journals

by IBEC - Institut de Bioenginyeria de Catalunya

11 years ago
SMARCD1, SMARCD2 and SMARCD3 proteins, cancer, SWI/SNF, C. elegans, AIRAPL protein

The nematode Caernorhabditis elegans is used in Dr. Julián Cerón’s laboratory as a model for several diseases. The group has recently published two articles, in Genetics and in Nature medicine.

New mechanism of antitumor action identified

by Vall d’Hebron

11 years ago
cancer, drug ABTL0812, Autophagy

By activating the PPAR receptors, ABTL0812 induces over-expression of TRIB3 protein, which binds to the Akt oncogene and inhibits the Akt/mTOR axis.

Investigación sobre la relación entre factores ambientales y cáncer

by Universidad de Huelva

11 years ago
cáncer, medioambiente, análisis de metales

Se trata de un estudio a nivel nacional junto al Instituto de Salud Carlos III de Madrid sobre la presencia de metales en los enfermos. La Universidad de Huelva analizará 10.000 muestras de uñas y 3...

CiQUS researchers describe on ChemBioChem a new prodrug strategy for controlling in vivo cytotoxicity.

by Center for Research in Biological Chemistry and Molecular Materials

11 years ago
tumoral cells, cancer, chemotherapeutic agents

One of the biggest challenges in the development of chemotherapeutic agents is to obtain highly selective species that selectively attack tumoral cells while showing low cytotoxicity against normal ce...

Innovative Approaches to Improve Cancer Patient Outcomes

by Vall d’Hebron

11 years ago
WIN 2016, symposia, cancer

WIN will address the most critical question facing clinical cancer research: Why the improvement of survival still remains limited for most cancer patients?

New tumor suppressor associates cancer and aging in the hematopoietic system

by Universidad de Oviedo

11 years ago
hematological tumor suppressor, protein AIRAPL, cancer, aging

New research led by the University of Oviedo has identified the protein AIRAPL as a new hematological tumor suppressor. The work published in ‘Nature Medicine' provides new biological keys concernin...

A new era of research in cancer genomics

by Parc Científic de Barcelona

11 years ago
cancer, genomics, somatic mutations

A study published in the prestigious journal Nature Communications –led by the Centro Nacional de Analisis Genómico (CNAG-CRG), located at the Barcelona Science Park (PCB), and the German Cancer R...

Researchers find out cause of mutations which are not in genetic material

by IBEC - Institut de Bioenginyeria de Catalunya

11 years ago
cancer, proteins, DNA, gene ADAR1

The gene identified (referred ADAR1) regulates the level of mutations in RNA, and it is a publisher gene. People with an excess of this gene have an imbalance in the composition of this molecule just ...