Mitochondria identified as key player in a rare disease causing microcephaly

by IRB Barcelona - Instituto de Investigación Biomédica

3 months ago
aneuploidies, microcephaly, Mosaic Variegated Aneuploidy (MVA), proteotoxic stress, autophagy

The study has identified the cellular mechanism explaining why certain errors in chromosome division can lead to microcephaly, a condition where the brain develops to a smaller than average size

Researchers at IRB Barcelona discover how mitochondria drive autophagy

by IRB Barcelona - Instituto de Investigación Biomédica

1 year ago
autophagy, mitochondria, CRISPR-Cas9, MFN1 and MFN2, sarcopenia, mitofusins

Using gene editing with CRISPR-Cas9, the team has been able to study these proteins without altering them or producing them in excess, thereby allowing observation of their true function.

The drug SAR405, the best inhibitor of autophagy

by IRB Lleida. Institut de Recerca Biomèdica

6 years ago
drug, autophagy, neurological diseases, cancer, UdL, IRBLleida

UdL research questions use of 3-methyladenine in studies because of its toxicity

New pathway to attack tumor cells identified

by CSIC - Centro Superior de Investigaciones Científicas

6 years ago
AbilityPharma, Autophagy, cells, cancer, stress

A study led by researchers from the Institut de Neurociències (INc-UAB), in collaboration with the Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), describes a new mechanism by which the an...

AbilityPharma publishes full characterization of mechanism of action of ABTL0812, a Phase II clinical inducer of cytotoxic autophagy in cancer cells, in Autophagy journal

by AbilityPharma

6 years ago
Autophagy, cancer, cytotoxic autophagy, lung, endometrial

The biopharmaceutical company Ability Pharmaceuticals SL announced today that the full description of the mechanism of action of ABTL0812 has been published in the prestigious Autophagy journal (impac...

COST Action BM1307 PROTEOSTASIS - 'European network to integrate research on intracellular proteolysis pathways in health and disease' – ends in April 2018

by CIC bioGUNE

8 years ago
COST Action PROTEOSTASIS BM1307, European network, Ubiquitin/Proteasome, autophagy, lysosomal systems

The COST Action PROTEOSTASIS BM1307, coordinated by Dr. Rosa Barrio (group leader at CIC bioGUNE) ended on the 24th of April 2018. This European network gathered 274 group members from almost all coun...

IRBLleida researchers open a new door to improve cancer treatment

by IRB Lleida. Institut de Recerca Biomèdica

10 years ago
cancer, autophagy

Researchers at the Pharmacology Unit IRBLleida have trials with several models of cell cultures, including some derived from tumors of patients, exposing them to media without nutrients and trophic fa...