One mutation or two? Researchers discover why some genes require one or two hits to promote cancer

by Centre for Genomic Regulation

​Cancer DNA - also known as the 'book of life' - is written in a language that is still being deciphered, which is why it remains a challenge to translate what genes say into physical traits that ...

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One mutation or two? Researchers in Spain discover why some genes require one or two hits to promote cancer

by IRB Barcelona - Instituto de Investigación Biomédica

The language in which the DNA book of life is written is still being deciphered, which is why it remains a challenge to translate what genes say into physical traits in the organism. For example, why ...

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Smoking During Pregnancy May Impact Fetal Growth through Changes in Placental Gene Expression

by ISGlobal - Instituto de Salud Global de Barcelona

A new study demonstrates links between maternal smoke, placental DNA methylation and poor birth outcomes

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Untwisting DNA reveals new force that shapes genomes

by Centre for Genomic Regulation

Advances in microscopy have enabled researchers to picture loops of DNA strands for the first time. The images reveal how the human genome organises itself in three-dimensional space at much higher re...

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The importance of DNA compaction in tissue formation

by IRB Barcelona - Instituto de Investigación Biomédica

​Researchers at IRB Barcelona identify that the expression of ancestral fragments of viral DNA results in a strong inflammatory response and causes breast tissue dysfunction.

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CNIO researchers discover the cause of neuronal death in a large proportion of familial ALS patients

by CNIO - Centro Nacional de Investigaciones Oncológicas

​The researchers attribute the loss of motor neurons in patients with Amyotrophic Lateral Sclerosis (ALS) to a new mechanism that blocks any cellular reaction that involves nucleic acids (DNA or RNA...

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Large-scale genetic study sheds light on the causes of hemorrhoids (piles)

by CIC bioGUNE

Hemorrhoidal disease (commonly referred to as hemorrhoids) affects a large portion of the population, for reasons that are mostly unknown. New research from an international collaboration identifies p...

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Identified the genetic mechanisms for the acquisition of resistance to antibiotics in H. parainfluenzae

by Hospital Universitari de Bellvitge

The work of the Epidemiology of Bacterial Infections research group of IDIBELL and HUB indicates that the bacteria could achieve the resistance through the acquisition of mobile DNA fragments.

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Cell Reports. DNA structure itself is involved in genome regulation, scientists find

by CNIO - Centro Nacional de Investigaciones Oncológicas

​TOP2A relieves negative supercoiling at gene promoters, resulting thus in an increase in the number of twists of the DNA strands. This is an obstacle to the continuous opening of the helix that pre...

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Nature Structural & Molecular Biology. An international study reveals how the ‘guardian’ of the genome works

by CNIO - Centro Nacional de Investigaciones Oncológicas

The background of the illustration is a photograph taken with the electron microscope showing DNA molecules decorated with MutS molecules, scanning the DNA for errors. The lower part shows the MutS st...

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Researcher Ramon Eritja publishes book about nucleic acids chemistry

by Institute for Advanced Chemistry of Catalonia (IQAC-CSIC)

The book “Nucleic Acids Chemistry” takes the most important aspects of the methodology of oligonucleotides synthesis, that is currently expanding by the endorsement of a dozen of new medicines, su...

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