The isoforms of the HP1 protein differentially regulate the organization and structure of heterochromatin

by IBEC - Institut de Bioenginyeria de Catalunya

9 years ago
HP1 proteins, chromatin, genome, DNA

Researchers from the Epigenetics and Cancer Biology Program of the Bellvitge Biomedical Research Institute (IDIBELL), led by Dr. Àlex Vaquero, have elucidated the role of HP1 proteins in relation to ...

Link between defects in DNA replication and loss of heterochromatin

by Centre for Genomic Regulation

9 years ago
cell division, epigenetics, DNA

Scientists reveal that a fault in the process that copies DNA during cell division can cause epigenetic changes that may be inherited for up-to five generations. They also identified the cause of thes...

Histone 1, the guardian of genome stability

by IRB Barcelona - Instituto de Investigación Biomédica

9 years ago
Genomic instability, cancer, histone 1, DNA

Genomic instability is the main risk factor for tumour development in humans. Therefore understanding its origin and exploring therapeutic targets is paramount. Histone 1 silences a region of the geno...

IRB Barcelona opens brand new laboratory for analysis of genomic 'big data'

by Parc Científic de Barcelona

9 years ago
bioinformatics, genomics, DNA, cancer, mutation

Researcher in the field of bioinformatics and genomics Fran Supek is starting his Genome Data Science (aGENDAS) laboratory at the Institute for Research in Biomedicine (IRB Barcelona), within the Str...

After the epigenome: the epitranscriptome

by IBEC - Institut de Bioenginyeria de Catalunya

9 years ago
epigenetics, DNA, proteins

In epigenetics, there there are “accents”, called DNA methylation, which means having a C or a methyl-C. The first one usually means that a gene is expressed and active, while the second one impli...

Novel gene causative for adrenal insufficiency syndrome and steroid-resistant nephrotic syndrome

by Vall d’Hebron

9 years ago
DNA, gene SGPL1, adrenal glands, kidney

The study included patients from Hospital Vall d’Hebron and from many other hospitals in different countries like UK, Turkey, Pakistan and Peru. Their DNA was sequenced and the defective gene SGPL1 ...

Genome Editing: Pressing the 'Delete' Button on DNA

by Centre for Genomic Regulation

9 years ago
DNA, living cells, software, CRISPETa, DECKO

Until recently, genomics was a «read-only» science. But scientists led by Rory Johnson at the University of Bern and the Centre for Genomic Regulation in Barcelona, have now developed a tool for qui...

CIC bioGUNE researchers uncover the molecular mechanism of PCNA protein sliding on DNA

by CIC bioGUNE

10 years ago
functional inhibitors, molecular mechanism, PCNA protein, DNA

The work, published in the journal Nature Communications, suggests modulator molecules of sliding as possible functional inhibitors. In the long term, the research may help to uncover PCNA inhibitors ...

Spanish scientists sequence the genome of the Iberian lynx, the most endangered felid

by IMIM - Institut Hospital del Mar d'Investigacions Mèdiques

10 years ago
genetic diversity, Iberian lynx, DNA, endangered felid

Genomic analysis of the Iberian lynx confirms that it is one of the species with the least genetic diversity among individuals, which means that it has little margin for adaptation. The research, whic...

Dr. Matilde Lleonart publishes a article about the resistance to the treatment of some kind of tumors

by Vall d’Hebron

10 years ago
cancer, resistance to therapy, DNA, stem cells, detoxification systems

In this article, the investigators propose different mechanisms responsible of the resistance to therapy. Cancer stem cells are resistant because are protected at a molecular level by potent detoxific...

New gene-editing technology partially restores vision in blind animals

by Fundació Clínic per a la Recerca Biomèdica

10 years ago
DNA, HITI, CRISPR-Cas9 system, blind animals

The new Salk technology is ten times more efficient than other methods at incorporating new DNA into cultures of dividing cells, making it a promising tool for both research and medicine. But, more im...

New polymers designed at CiQUS explore their application in gene therapy

by Center for Research in Biological Chemistry and Molecular Materials

10 years ago
polymers, gene therapy, DNA

Scientists at the Singular Research Center Biological and Molecular Materials at the University of Santiago de Compostela (CiQUS) and the University of Birmingham Chemical developed a new and fast met...