CIC bioGUNE researchers uncover the molecular mechanism of PCNA protein sliding on DNA

by CIC bioGUNE

The work, published in the journal Nature Communications, suggests modulator molecules of sliding as possible functional inhibitors. In the long term, the research may help to uncover PCNA inhibitors ...

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Spanish scientists sequence the genome of the Iberian lynx, the most endangered felid

by IMIM - Institut Hospital del Mar d'Investigacions Mèdiques

Genomic analysis of the Iberian lynx confirms that it is one of the species with the least genetic diversity among individuals, which means that it has little margin for adaptation. The research, whic...

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Dr. Matilde Lleonart publishes a article about the resistance to the treatment of some kind of tumors

by Vall d’Hebron

In this article, the investigators propose different mechanisms responsible of the resistance to therapy. Cancer stem cells are resistant because are protected at a molecular level by potent detoxific...

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New gene-editing technology partially restores vision in blind animals

by Fundació Clínic per a la Recerca Biomèdica

The new Salk technology is ten times more efficient than other methods at incorporating new DNA into cultures of dividing cells, making it a promising tool for both research and medicine. But, more im...

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New polymers designed at CiQUS explore their application in gene therapy

by Center for Research in Biological Chemistry and Molecular Materials

Scientists at the Singular Research Center Biological and Molecular Materials at the University of Santiago de Compostela (CiQUS) and the University of Birmingham Chemical developed a new and fast met...

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El DNA no reparado se concentra y aísla en un nuevo compartimento nuclear

by Instituto de Investigación Marqués de Valdecilla

El grupo de investigación IDIVAL “Biología Celular del Núcleo”, co-liderado por los Profs. Miguel Lafarga y María T. Berciano, con la participación de los miembros del grupo Jorge Mata-Garrid...

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Cells check DNA segregation at the end of their division

by Centre for Genomic Regulation

Researchers at the Centre for Genomic Regulation (CRG) are shedding new light on the cell division process, key in embryonic development, and the growth and proliferation of tumors. The study, to be p...

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Scientists find a new molecular mechanism involved in the development of cancer

by UPF - Universitat Pompeu Fabra

The Computational Genomics research group at Pompeu Fabra University has discovered new alterations linked to cancer and has revealed the importance of transcriptome in the development of tumours.

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CNIO scientists have discovered a code of signals that regulates genome duplication

by CNIO - Centro Nacional de Investigaciones Oncológicas

The balance between two modifications in proteins — ubiquitination and SUMOylation — regulates cellular DNA copying. The USP7 protein travels with the machinery required to copy the DNA and favour...

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CNIO scientists use the Internet network theory to decipher the first epigenetic communication network

by CNIO - Centro Nacional de Investigaciones Oncológicas

The scientists employed the algorithms used to analyse the influence and popularity of websites, such as Wikipedia or social networks. These results provide the basis for exploring communication betwe...

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Researchers find out cause of mutations which are not in genetic material

by IBEC - Institut de Bioenginyeria de Catalunya

The gene identified (referred ADAR1) regulates the level of mutations in RNA, and it is a publisher gene. People with an excess of this gene have an imbalance in the composition of this molecule just ...

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Cut & paste is now for DNA dark matter too

by Centre for Genomic Regulation

Researchers from the Centre for Genomic Regulation have adapted the most revolutionary genome-editing technique to DNA dark matter, too.

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