One mutation or two? Researchers discover why some genes require one or two hits to promote cancer

by Centre for Genomic Regulation

3 years ago
DNA, mutations, Cancer

Cancer DNA - also known as the 'book of life' - is written in a language that is still being deciphered, which is why it remains a challenge to translate what genes say into physical traits that ...

One mutation or two? Researchers in Spain discover why some genes require one or two hits to promote cancer

by IRB Barcelona - Instituto de Investigación Biomédica

3 years ago
DNA, genes, mutations, Researchers, Cancer

The language in which the DNA book of life is written is still being deciphered, which is why it remains a challenge to translate what genes say into physical traits in the organism. For example, why ...

IRB Barcelona participates in a study that illuminates origins of lung cancer in never smokers

by IRB Barcelona - Instituto de Investigación Biomédica

3 years ago
genomic analysis, mutations, never smokers, lung cancer

A genomic analysis of lung cancer in people with no history of smoking has found that a majority of these tumors arise from the accumulation of mutations caused by natural processes in the body.

First comprehensive map of amyloid plaque mutations opens new avenues for early detection of Alzheimer’s disease

by IBEC - Institut de Bioenginyeria de Catalunya

4 years ago
Alzheimer, mutations, amyloid beta peptide

A study published in the journal eLife made all the possible mutations in the amyloid beta peptide and tested how they influence its aggregation into plaques, a pathological hallmark of Alzheimer’s ...

A third of the world’s population carries mutations associated with retinal dystrophies

by DBGen Ocular Genomics

5 years ago
mutations, retinal dystrophies, personalized medicine

A very recent study published in the scientific journal PNAS highlights an estimate, on a global scale, of the frequency of individuals carrying pathogenic mutations responsible for inherited re...

Researchers perform thousands of mutations to understand amyotrophic lateral sclerosis

by IBEC - Institut de Bioenginyeria de Catalunya

5 years ago
amyotrophic lateral sclerosis, ALS, neurodegenerative disease, mutations

Researchers from IBEC and CRG in Barcelona use a technique called high-throughput mutagenesis to study Amyotrophic Lateral Sclerosis (ALS), with unexpected results.

RAD51 as a biomarker in extending PARP inhibitors to additional tumor subtypes

by VHIO

6 years ago
inhibitors, cancer, mutations, neoplasms

Thanks to continued progress in more precisely defining tumor subtypes and thus achieving an increasingly in-depth understanding of the complex biological systems that underlie cancer development, cur...

Researchers find a new human androgen receptor structure, key target for the treatment of prostate cancer

by Universitat de Barcelona

8 years ago
mutations, prostate cancer, androgen insensitivity syndromes

A team led by researchers of the Institute of Biomedicine of the University of Barcelona (IBUB) and the Research Institute of the Hospital de la Santa Creu i Sant Pau (IIB Sant Pau) shows for the fi...

The fundamental causes of human ageing explained

by UPF - Universitat Pompeu Fabra

8 years ago
natural selection, human ageing, genomics, mutations

Natural selection favours fragile and unhealthy old age if it is due to mutations that are beneficial during childhood. As of 40-50 years of age, natural selection is blind because we have already pas...