UB researchers identify a key protein in the inflammatory response to infections

by Universitat de Barcelona

1 month ago
Polμ protein, macrophages, reactive oxygen species (ROS), interferonopathies, type I interferons, inflammation

A deficiency of Polμ protein could be the cause of certain autoinflammatory diseases, conditions in which the immune system is activated inappropriately, leading to chronic inflammation and tissue da...

CNIC scientists uncover a novel mechanism involved in inflammation resolution

by Centro Nacional de Investigaciones Cardiovasculares - CNIC

4 months ago
phagocytosing, type I interferon (IFN‑I), Macrophages, ISG15

A study published in Immunity reveals that type I interferons (IFN‑I) help resolve inflammation by inducing changes in macrophage mitochondria

Discovery of a Therapeutic Pathway to Enhance the Cardioprotective Potential of HDL in People with Familial Hypercholesterolemia

by Hospital de la Santa Creu i Sant Pau

2 years ago
“good” cholesterol HDL, “bad” cholesterol (LDL), Heterozygous familial hypercholesterolemia, PCSK9 protein, macrophages

A new study reveals a therapeutic pathway that could improve the cardioprotective potential of “good” cholesterol (carried by HDL) in people with familial hypercholesterolemia, a genetic disorder ...

A gene is identified that that blocks acute inflammation and its progression to chronic inflammation

by Fundació Clínic per a la Recerca Biomèdica

3 years ago
gene ZEB1, macrophages, chronic inflammation

An IDIBAPS study published in Nature Communications shows that the ZEB1 gene regulates the immune system’s inflammatory response.

Cell 'canibalism' educates our defenses

by Centro Nacional de Investigaciones Cardiovasculares - CNIC

9 years ago
macrófagos, Phagocytosis, immune cells, macrophages

Phagocytosis is a biological mechanism whereby specialized cells ingest and degrade old, dead, or damaged cells to prevent tissue damage due to their accumulation. But phagocytosis appears to also hav...

A scientific team describes a new molecular mechanism to fight bacterial infections

by Universitat de Barcelona

9 years ago
antibacterial mechanism, macrophages, immune system, Salmonella enterica serovar Typhimurium

An international team led by the University if Barcelona has identified a new antibacterial mechanism that protects macrophages – defense cells in the immune system- from the infection of the bacter...