Vitamin D receptor inhibition helps prevent vascular calcification in chronic kidney disease and reduce mortality

by IRB Lleida. Institut de Recerca Biomèdica

The novelty of this research is that the vitamin D receptor influences calcification locally, exclusively in the smooth muscle cells of the arteries. These cells are the ones that undergo a phenotypic...

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A combination therapy, new option for patients with advanced urothelial cancer who cannot receive conventional chemotherapy

by Hospital de la Santa Creu i Sant Pau

Researcher has been able to verify that the combination of two drugs, enfortumab vedotin and pembrolizumab, which had previously shown benefits in survival in second-line treatment and in cases of adv...

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Mineralys Therapeutics Announces Expansion of Planned Phase 2 Trial of Lorundrostat Alone and in Combination with SGLT2 Inhibitor to Treat Patients with Chronic Kidney Disease (CKD)

by Ysios Capital

Mineralys Therapeutics today announced details of an expanded two-part Phase 2 clinical trial for lorundrostat as a potential therapy to treat patients with Stage 2 to 4 chronic kidney disease (CKD), ...

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The natural antioxidant L-Ergothioneine prevents the formation of cystine stones in a murine model of cystinuria

by IDIBELL - Institut d’Investigació Biomèdica de Bellvitge

El tratamiento con L-Ergotioneina consigue incrementar la solubilidad de la cistina en la orina, evitando así la formación de cálculos o retrasando su aparición.

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Crean riñones humanizados en embriones de cerdo durante 28 días

by Agencia Sinc

Han logrado por primera vez cultivar un órgano sólido humanizado dentro de otra especie utilizando células madre pluripotentes y edición genética CRISPR Cas9. Los riñones resultantes son estruct...

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Una nueva terapia génica para pacientes con síndrome nefrótico con mutaciones en NPHS2

by Revista Genética Médica

Un equipo de investigadores de la Universidad de Bristol, en Reino Unido, ha desarrollado una terapia génica con potencial para el tratamiento de pacientes con síndrome nefrótico con mutaciones en ...

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El Hospital de Bellvitge y el Banco de Sangre impulsan una terapia celular líder para luchar contra las infecciones en pacientes trasplantados

by Hospital Universitari de Bellvitge

Se ha administrado un tratamiento de terapia celular avanzada llamado ViroTCell, que toma defensas de personas sanas y las activa para que actúen como medicamento contra las infecciones virales de lo...

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Am-Pharma announces updated clinical development strategy

by Ysios Capital

Advancing ilofotase alfa into a Phase 2 study for lead indication cardiac surgery-associated renal damage

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Renalyse has successfully closed an investment round of 1 M€ led by Mind the Gap and with participation from GENESIS Ventures and the Eurostars program

by GENESIS Biomed

Renalyse, also known as CreatSens Health, has concluded an investment round led by the Mind the Gap program of the Botín Foundation, with participation from GENESIS Ventures and the Eurostars program...

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First-in-class HIF-2α inhibitor improves outcomes in patients with previously treated advanced clear cell renal cell carcinoma

by VHIO

Presentados en el Congreso ESMO 2023, los resultados del estudio de fase III LITESPARK-005 muestran que el tratamiento con belzutifan frente a everolimus mejora significativamente la supervivencia lib...

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