Early differentiated T Lymphocytes predict prognosis in patients with pneumonia

Researchers from the Research Institute of the Hospital de la Santa Creu i Sant Pau – IIB Sant Pau, the Immunology Department and the Geriatrics Unit of the Internal Medicine Department of the same hospital have identified that the increased levels of CD28+ CD27+ T lymphocytes early differentiated is associated with a better prognosis in patients older than 65 years who are admitted for pneumonia.

This is the conclusion of a prospective study -carried out as a FIS project of the Carlos III Health Institute- published by Journal of Leukocyte Biology, whose principal authors are Laura Martínez Martínez, Olga H. Torres and Teresa Franco – Leyva.

These researchers have verified that patients who had a higher count of these immune system cells at the time of hospital admission had better survival rates, as well as a lower rate of readmission, both at two months and one year follow-up after hospital admission.

These findings suggest that levels of early differentiated CD28+ CD27+ T lymphocytes could be a biomarker that can help better stratifying risk and monitoring these patients.

The work analyzes data from 97 patients admitted to the Hospital de Sant Pau during the years 2019 and 2020.

Reference article

Franco-Leyva T, Torres OH, Saez Prieto ME, et al. Early differentiated CD28+ CD27+ T lymphocytes as a biomarker for short and long-term outcomes in older patients with pneumonia. J Leukoc Biol. 2022;1-8. https://doi.org/10.1002/JLB.5MA0422-370R