Human Platelet Lysate (hPL): A Clinically Aligned, Xeno-Free Alternative to FBS

Designed for Scalable, Reproducible Cell Culture From Research to Clinical Manufacturing

Human Platelet Lysate (hPL) is a human-derived, xeno-free alternative to fetal bovine serum (FBS), developed to address the scientific, ethical, and translational limitations of animal-derived supplements. With a physiologically relevant growth factor profile and high batch consistency, hPL enables robust and reproducible expansion of human cells while supporting modern regulatory and translational expectations.

Key benefits:

Xeno-free
All pathogen-inactivated
Fibrinogen-depleted (no heparin required)
Anticoagulant-free & Clot-free
GMP - grade manufacturing
100% EU donor origin

Compatible with MSCs, T cells, NK cells, iPSCs, fibroblasts, and widely used cell lines.

hPL GOLD & hPL PLATINUM

Category	GOLD (Research & Clinical)	PLATINUM (Research & Clinical)
HPL Type	Premium hPL generated from platelet concentrate (transfusion grade). Both hPL Gold and Platinum have been successfully applied across multiple advanced cell types.	Next generation platelet lysate that contains an even higher concentration of growth factors, resulting in a different composition. Both hPL Gold and Platinum have been successfully applied across multiple advanced cell types.
Media compatibility	Low-Ca²⁺ media such as DMEM/F-12, IMDM, Ham’s F-12, RPMI-1640, etc.	Broad media compatibility including DMEM, DMEM/F-12, αMEM, IMDM, Ham’s F-12.
Intended use	Research Grade: For optimal cost-effectiveness, Research grade hPL is the best choice. The products have the same composition as their clinical counterparts and are therefore equally efficient. Applications include R&D, method development, and translational research. Clinical Grade: Produced with more extensive testing, documentation, and traceability. Suitable for early clinical workflows, clinical manufacturing, and ATMP production.
Formats	100 mL, 500 mL	180 mL
Visual reference

hPL vs FBS

Superior Cell Expansion

≈2× faster proliferation with hPL versus FBS
Requires fewer supplements

High Batch-to-Batch Consistency

Provides superior batch-to-batch consistency compared to FBS, enabling predictable performance for advanced in vitro models and scalable bioprocesses
Wiley Online Library

hPL Has Been Successfully Applied Across Multiple Advanced Cell Types

UCB CD34+

Manufacturing Quality & Regulatory Alignment

Quality & Safety

NAT testing for HIV, HBV, and HCV
Pathogen inactivation
Closed system
Full donor & batch traceability
Non remunerated EU donors

Regulatory & Ethical Fit

Aligned with modern translational and regulatory expectations
Supports 3Rs/NAMs and human-relevant model systems

GMP-Aligned Production

Compliant with applicable standards:
- ISO 13485 & ISO 20399
- European Pharmacopoeia
Closed-system manufacturing workflow
Scalable batch up to 200 L

Integrate A Human-Relevant, Xeno-Free Supplement Into Your Manufacturing Or Therapeutic Workflow

Whether you are developing advanced in vitro models, scaling cell therapy processes, or transitioning away from FBS, hPL GOLD and PLATINUM provide a high-performance, reproducible and clinically aligned solution.