he First Specific LSD1 Inhibitor to Enter the Clinic.

Barcelona, Spain. January 16th, 2014. ORYZON, a biopharmaceutical company with a strong focus on epigenetics, hasannounced that has received the approval from the British Drug Agency (MHRA) on January 15th, 2014 to initiate a Phase I/IIA clinical trial of ORY-1001, a novel and highly selective LSD1 inhibitor, in patients with relapsed or refractory acute leukemia in the United Kingdom.

The company got the approval from the Spanish Drug Agency (AEMPS) a few weeks ago. This first-in-human trial is currently open at the Hospital Vall d’Hebron inBarcelona, Spain and additional study sites in Spain and in the United Kingdom will be incorporated shortly.

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