80% of the cancer cell lines used in research 
closely resemble their tissue-of-origin

by IRB Barcelona - Instituto de Investigación Biomédica

In cancer research, cell lines are an essential tool to study tumour biology and to test drugs or therapeutic approaches. Led by the ICREA researcher Fran Supek, the Genome Data Science Laboratory at ...

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DRUG RESISTANCE: In vitro preclinical studies identified BRCA2 amplification as a potential mechanism of PARP inhibitor resistance in BRCA2 mutant cancer cell lines

by OncoDNA

Amplification of the mutation-carrying BRCA2 allele promotes RAD51 loading and PARP inhibitor resistance in the absence of reversion mutations.

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