Study identifies PARG as a new target to enhance chemotherapy in colorectal cancer

by Hospital Universitari Germans Trias i Pujol

4 months ago
Colorectal cancer, 5-fluorouracil and irinotecan (FUIRI)., chromatin, enzyme PARG (poly-ADP-ribose glycohydrolase)

Overall, the findings position PARG as a potential new therapeutic target in colorectal cancer and open the door to the development of combined strategies integrating PARG inhibition with standard che...

Insights into the function of the new chromatin remodeling complex in plants

by Centro de Biotecnología y Genómica de Plantas CBGP

6 years ago
vegetals, chromatin, plants, gene, environmental

Histone acetylation is an evolutionarily conserved covalent modification associated with the activation of gene expression

A study suggests that epigenetic treatments could trigger the development of aggressive tumours

by IRB Barcelona - Instituto de Investigación Biomédica

8 years ago
chromatin, epigenetic treatments, aggressive tumours

A team headed by ICREA researchers Salvador Aznar Benitah and Fran Supek concludes that care should be taken with drugs that inhibit epigenetic factors. Published in Nature Cell Biology, the study is ...

Researchers identify a new NF-kB pathway regulatory mechanism linked to SirT6

by IBEC - Institut de Bioenginyeria de Catalunya

9 years ago
NF-κB pathway, accelerated cellular aging, SirT6 protein, chromatin

Researchers from the Epigenetics and Cancer Biology Program of the Bellvitge Biomedical Research Institute (IDIBELL), led by Dr. Àlex Vaquero, have proposed a new regulation mechanism of the NF-κB p...

The isoforms of the HP1 protein differentially regulate the organization and structure of heterochromatin

by IBEC - Institut de Bioenginyeria de Catalunya

9 years ago
HP1 proteins, chromatin, genome, DNA

Researchers from the Epigenetics and Cancer Biology Program of the Bellvitge Biomedical Research Institute (IDIBELL), led by Dr. Àlex Vaquero, have elucidated the role of HP1 proteins in relation to ...