Adult neurogenesis is the generation and integration of new neurons once the embryonic development of the brain has concluded. This phenomenon is driven by the proliferation, survival and differentiation of a population of neural stem cells that remain in the adult brain and reside in specific microenvironments (the neurogenic niches).
“Deciphering the molecular foundations of the regulated activation that neural stem cells must undergo to proliferate, survive and generate new cellular progeny in adult brains is of great relevance. This helps us understand why the brain's regenerative capacity is limited and what we can do to increase it in aging or neurodegenerative diseases," comments Eva Porlan, one of the lead and corresponding authors of the study, a researcher at CBMSO (UAM- CSIC).
Kidins220, for neuronal survival and differentiation
KIDINS220 ( Kinase D interacting substrate of 220 kDa ) is a protein that regulates several molecular pathways, and its expression is altered in various neurodegenerative diseases, such as Huntingon's, Alzheimer's and chronic adult hydrophephaly, SINO syndrome in children, in neuropsychiatric diseases, such as schizophrenia, as well as in cancer.
“ In the study, mice with low levels of Kidins220 showed severe neurogenic deficits and impaired spatial memory. "Our results shed light on new functions of Kidins220, a gene related to human neurological, neuropsychiatric and neurodegenerative disorders, and place Kidins220 as a molecular player in the process of adult neurogenesis, which may help pave the way towards neurorepair," he concludes . Teresa Iglesias, CSIC research professor at the IIBM and head of the CIBERNED group.
This CIBER collaborative work in the areas of Neurodegenerative (CIBERNED) and Cardiovascular (CIBERCV) has been co-led by researchers from the Severo Ochoa Molecular Biology Center (CBMSO) and the Sols-Morreale Biomedical Research Institute (IIBM), both joint centers from the Autonomous University of Madrid (UAM) and the Higher Council for Scientific Research (CSIC), and the participation of research personnel from other institutions in Spain and abroad.
Image: Coral López Fonseca (Right) and Ana Simón García (Left), two of the first signatories of the study, with her partner Celia López Menéndez, a collaborating researcher, and the leaders of the work Teresa Iglesias, from the IIBM (CSIC-UAM) and head of CIBERNED group, and Eva Porlan, from the CBMSO (CSIC-UAM).
Bibliographic reference: Del Puerto, A; Lopez-Fonseca, C; Simón-García, A. et al . Kidins220 sets the threshold for survival of neural stem cells and progenitors to sustain adult neurogenesis . Cell Death & Disease , August 2023 Doi: 10.1038/s41419-023-05995-7
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