Travis Stracker: 'We want to understand how genomic instability causes diseases such as cancer'

The research performed by biologist Travis Stracker (Cleveland, OH, USA, 1974), head of the Genomic Instability and Cancer lab at IRB Barcelona, focuses on understanding of how cells prevent the accumulation of genomic instability.

This instability is caused by the accumulation of unrepaired mutations and errors in chromosomes. DNA damage occurs during each cell division or through exposure to exogenous agents, such as solar radiation, and chemical substances, such as tobacco smoke.

Stracker studies how cells prevent the accumulation of genomic instability by identifying the basic mechanisms that maintain the genome: “We have a genome consisting of millions of base pairs and it’s so delicate and susceptible: one mistake in the wrong place can have severe consequences.

In addition, his team studies how genomic instability influences cancer and rare diseases such as microcephaly. Stracker believes that his findings may be able to help provide patients with better treatments in the future.

Creativity, music and science

Barcelona is a great place in which to do research, says the scientist, who is very happy to be living in a city that inspires creativity. In this regard, he thinks that there are parallels between music and science, saying “in both we have to work well as a team, depending on the individual talents of each of the group members, and we have to use creativity and improvisation in order to tackle challenging questions”.

Stracker shows the music tapes that his friends have given him over the years that reflect how far technology has progressed. “I look forward to seeing what the next 25 years bring in terms of technological development”, he says.

"Meet Our Scientists" is a series of short videos that presents the group leaders at IRB Barcelona. The videos seek to showcase the vision, passion, character and talent of the scientists working at the centre, as well as to disseminate biomedical research.

This video has been supported by the Spanish Foundation of Science and Technology (FECYT) and the Ministry of Economy and Competitiveness.

About IRB Barcelona

Created in 2005 by the Generalitat de Catalunya (Government of Catalonia) and University of Barcelona, IRB Barcelona is a Severo Ochoa Centre of Excellence, a seal that was awarded in 2011. The institute is devoted to conducting research of excellence in biomedicine and to transferring results to clinical practice, thus improving people’s quality of life, while simultaneously promoting the training of outstanding researchers, technology transfer, and public communication of science. Its 25 laboratories and seven core facilities address basic questions in biology and are orientated to diseases such as cancer, metastasis, Alzheimer’s, diabetes, and rare conditions. IRB Barcelona is an international centre that hosts 400 employees and 32 nationalities. It is located in the Barcelona Science Park. IRB Barcelona forms part of the Barcelona Institute of Science and Technology (BIST) and the “Xarxa de Centres de Recerca de Catalunya” (CERCA).

Image: Travis Stracker, head of the Genomic Instability and Cancer lab at IRB Barcelona