EntreChem and Servier explore the biocatalytic toolbox for the asymmetric synthesis of Ivabradine

EntreChem SL, a biotechnology company that develops new biocatalytic processes, has published in Advanced Synthesis & Catalysis, the results of a collaborative research with Servier focused on enzymatic routes to improved syntheses of the heart-rate reducing drug Ivabradine. The key step involves a lipase-catalyzed kinetic resolution by alkoxycarbonylation of a racemic primary amine, or alternatively, the dynamic kinetic resolution by asymmetric bioamination of an aldehyde precursor catalyzed by a transaminase.

The results highlight the opportunities offered by enzymes for synthesis of chiral drugs. The transaminase-catalyzed bioamination is particularly powerful, since it enables a process that overcomes the yield hurdles of kinetic resolutions or crystallization approaches.

[ Go to pubication ]