EntreChem reports Ruthenium-KRED concurrent one-pot/one-step cascade for chiral alcohols

EntreChem, a biotechnology company developing new biocatalysis applications, has published in Angewandte Chemie Int. Ed., the first genuine example of concurrent one-pot/one-step cascade reaction involving a Ruthenium metal catalyst and a ketoreductase biocatalyst with excellent conversion and enantioselectivity, under mild, eco-friendly conditions and without the use of external cofactors.

The results, part of the EU ITN European Industrial Doctorates Network BIOCASCADES, highlight the opportunities offered by crossing the frontier between a multi-step processes to a truly one-pot/one-step cascade, with metal and biocatalyts coexisting from the beginning of the reaction. This kind of metal-biocatalyst cascades could represent a highly effective alternative to currently used encapsulation or compartmentalization techniques.

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