One mutation or two? Researchers discover why some genes require one or two hits to promote cancer

by Centre for Genomic Regulation

​Cancer DNA - also known as the 'book of life' - is written in a language that is still being deciphered, which is why it remains a challenge to translate what genes say into physical traits that ...

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One mutation or two? Researchers in Spain discover why some genes require one or two hits to promote cancer

by IRB Barcelona - Instituto de Investigación Biomédica

The language in which the DNA book of life is written is still being deciphered, which is why it remains a challenge to translate what genes say into physical traits in the organism. For example, why ...

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IRB Barcelona participates in a study that illuminates origins of lung cancer in never smokers

by IRB Barcelona - Instituto de Investigación Biomédica

​A genomic analysis of lung cancer in people with no history of smoking has found that a majority of these tumors arise from the accumulation of mutations caused by natural processes in the body.

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First comprehensive map of amyloid plaque mutations opens new avenues for early detection of Alzheimer’s disease

by IBEC - Institut de Bioenginyeria de Catalunya

A study published in the journal eLife made all the possible mutations in the amyloid beta peptide and tested how they influence its aggregation into plaques, a pathological hallmark of Alzheimer’s ...

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A third of the world’s population carries mutations associated with retinal dystrophies

by DBGen Ocular Genomics

​A very recent​ study published in the scientific journal PNAS highlights an estimate, on a global scale, of the frequency of individuals carrying pathogenic mutations responsible for inherited re...

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Researchers perform thousands of mutations to understand amyotrophic lateral sclerosis

by IBEC - Institut de Bioenginyeria de Catalunya

Researchers from IBEC and CRG in Barcelona use a technique called high-throughput mutagenesis to study Amyotrophic Lateral Sclerosis (ALS), with unexpected results.

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RAD51 as a biomarker in extending PARP inhibitors to additional tumor subtypes

by VHIO

Thanks to continued progress in more precisely defining tumor subtypes and thus achieving an increasingly in-depth understanding of the complex biological systems that underlie cancer development, cur...

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Researchers find a new human androgen receptor structure, key target for the treatment of prostate cancer

by Universitat de Barcelona

A team led by researchers of the Institute of Biomedicine of the University of Barcelona (IBUB) and the Research Institute of the Hospital de la Santa Creu i Sant Pau (IIB Sant Pau) shows for the fi...

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The fundamental causes of human ageing explained

by UPF - Universitat Pompeu Fabra

Natural selection favours fragile and unhealthy old age if it is due to mutations that are beneficial during childhood. As of 40-50 years of age, natural selection is blind because we have already pas...

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