New synthetic methodology for obtaining cycloalcohols based on palladium-catalysed 'tandem' reactions

CiQUS researchers have developed a new catalytic methodology based on palladium complexes, through which it is possible to carry out tandem cycloisomerisation/cross-coupling processes on a special type of alkylidenecyclopropanes, leading to the production of different cycloalcohols.

The study led by CiQUS PI, Fernando López and José Luis Mascareñas, demonstrates the crucial influence that ligands attached to the metal centre have on the control of the evolution of cyclopalladium intermediates in these catalytic processes. This new synthetic methodology has high potential for the rapid and efficient preparation of cyclic alcohols and amines.

Reference

Felipe Verdugo, Ricardo Rodiño, Martín Calvelo, José Luis Mascareñas and Fernando López; Palladium-Catalyzed Tandem Cycloisomerization/Cross-Coupling of Carbonyl-and Imine-Tethered Alkylidenecyclopropanes, Angewandte Chemie Int. Ed. Wiley. 2022. https://doi.org/10.1002/anie.202202295