A new approach to metastatic melanoma discovered

by IMIM - Institut Hospital del Mar d'Investigacions Mèdiques

​Combining chemotherapy and BRAF oncogene inhibitors is a very effective strategy for fighting metastatic melanoma, the leading cause of death from skin cancer in the world.

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A protein that facilitates DNA repair may potentiate chemotherapy

by CNIO - Centro Nacional de Investigaciones Oncológicas

​The PrimPol protein helps the cell to survive the damage caused by chemotherapy The researchers want to make tumour cells more sensitive to cancer treatments by repressing PrimPol

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MEET A HERO: Grant, 2 year old at diagnosis

by Oncoheroes Biosciences

"Upside down," said Grant looking at himself in the mirror and pointing at his Spiderman T-shirt while standing up on a hospital bed. Grant Gossling was 2 years old when he was diagnosed with high-ris...

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Identified the cellular process by which Cisplatin chemotherapy causes neuronal damage

by Hospital Universitari de Bellvitge

Once the mechanism has been described by a team from IDIBELL, ICO, HUB, and UAB, new strategies can be designed to alleviate the adverse effects of Cisplatin, one of the most common drugs in chemoth...

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An international clinical trial extends the effectiveness of immunotherapy to more lung cancer patients

by CNIO - Centro Nacional de Investigaciones Oncológicas

Combining immunotherapy with chemotherapy in patients with metastatic squamous cell carcinoma "significantly increases" the survival of patients, write the authors in The New England Journal of Medici...

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Hospital Clínic will implement a new genomic test to predict response to treatment in breast cancer

by Fundació Clínic per a la Recerca Biomèdica

Researchers from Hospital Clínic and IDIBAPS lead an international study in which they have developed a genomic test to predict the response to chemotherapy in breast cancer. Hospital Clínic of Barc...

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Scientists discover a cause of multiple resistance to cancer chemotherapy

by IBEC - Institut de Bioenginyeria de Catalunya

The introduction of cancer chemotherapy was a revolution for the treatment of this disease in those cases in which the cure is no longer possible only with the mere extirpation of the tumor. Chemother...

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The absence of a protein points out the prognosis of liver cancer patients

by CIMA - Centro de Investigación Médica Aplicada

Using proteome technology, CIMA researchers have established the mechanisms that favor tumor growth and resistance to chemotherapy

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CNIO scientists discover a new mechanism of resistance to chemotherapy

by CNIO - Centro Nacional de Investigaciones Oncológicas

Óscar Fernández-Capetillo’s team reports that ATR kinase inhibitors are more effective in cells with high levels of CDC25A protein expression. ATR inhibitors were previously developed at the CNIO ...

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The detection of a genetic alteration in blood samples predicts resistance to treatment in metastatic prostate cancer

by Fundació Clínic per a la Recerca Biomèdica

The detection of TMPRSS2-ERG in the blood of patients with resistant metastatic prostate cancer predicts resistance to taxanes, such as docetaxel, and may be useful for selecting the best treatment op...

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A genetic test at the time of diagnosis, useful for predicting treatment response in breast cancer

by Fundació Clínic per a la Recerca Biomèdica

Researchers have shown that the biology identified with genomic data is the most significant predictor of treatment response and survival beyond the 4-5 variables that are currently used in clinical p...

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New anti-carcinogenic compounds with low toxicity that may decrease the side effects of chemotherapy

by Universitat Jaume I

The designed compounds have particularly high therapeutic effects on tumour cells of breast and colon and can be the basis for the development of oncological drugs of low toxicity and high selectivity...

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