Targeted therapies improve efficacy in early-phase clinical trials driven by molecular patient selection

by VHIO

Researchers at VHIO have published an article in the journal European Journal of Cancer on the evolution of targeted therapies in early-phase clinical trials. The study shows a progressive improvement...

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Purified Omega-3 Treatment Reduces Cardiac Damage After a Heart Attack by Acting Directly on the Heart

by Hospital de la Santa Creu i Sant Pau

A type of omega-3 fatty acid found in oily fish, used as a medication to lower triglycerides, may directly protect the heart after a heart attack. A study led by the Research Institute of Sant Pau (IR...

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Protein’s role in male reproductive ageing identified

by Universitat Autònoma de Barcelona (UAB)

A study by the UAB and the IJC demonstrates that SIRT7 is a key regulator of the quality of male germ cells and that the deficiency of this protein during ageing can lead to a functional decline in sp...

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A multicentre study confirms the low incidence of HIV among PrEP users

by Fundació Clínic per a la Recerca Biomèdica

A Spanish multicentre study confirms that HIV infections among people using pre-exposure prophylaxis (PrEP) are uncommon and are mainly associated with interruptions or difficulties in adherence to pr...

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KRAS degradation induces rapid lung cancer regression in preclinical mouse models

by IRB Barcelona - Instituto de Investigación Biomédica

It has been demonstrated that eliminating mutated KRAS protein using PROTACs induces rapid tumour regression in mouse models of lung adenocarcinoma

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Un estudio preclínico abre la puerta a tratamientos personalizados de la hipertensión en hombres y mujeres

by INCLIVA

Este estudio muestra que la hipertensión arterial altera el funcionamiento de los vasos sanguíneos renales tanto en machos como en hembras, aunque no lo hace de la misma manera. En ambos casos se ob...

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Hallada una proteína clave para la recuperación del corazón tras un ataque cardíaco

by Instituto de Biomedicina de Sevilla - IBIS

El estudio apunta a Orai1 como un regulador esencial para regenerar nuevos vasos sanguíneos necesarios para reparar el corazón después de un infarto.

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Opening the door to new therapeutic strategies in patients with bronchiectasis

by IMIM - Institut Hospital del Mar d'Investigacions Mèdiques

People diagnosed with bronchiectasis show loss of muscle mass early on and in mild and moderate stages of this respiratory disease. This is why it is so important to understand the molecular mechanism...

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Promising results for a novel bispecific antibody

by VHIO

The HERIZON-GEA-01 open-label, phase 3 clinical trial was designed to compare first-line treatment with the bispecific antibody zanidatamab plus chemotherapy with or without PD‐1 monoclonal antibody...

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Fat molecule inside cell nucleus shifts with cell division

by Centre for Genomic Regulation

invResearchers have shown that a type of fat molecule, long associated with signalling at the cell's outer membrane, also operates inside the nucleus on a schedule that matches the rhythm of cell divi...

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The left and right ventricles differ in their ability to withstand the effects of cardiac arrest

by Centro Nacional de Investigaciones Cardiovasculares - CNIC

The findings, published in Cardiovascular Research, show that the right ventricle has greater metabolic resilience than the left during cardiac arrest caused by ventricular fibrillation.

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A new way to observe the release of proteins encapsulated in nanoparticles

by Institute for Advanced Chemistry of Catalonia (IQAC-CSIC)

Precision medicine aims to transport therapeutic agents, such as molecules, proteins or RNA, to the exact place where they need to act within the body. One of the most promising strategies is the use ...

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