KRAS degradation induces rapid lung cancer regression in preclinical mouse models

by IRB Barcelona - Instituto de Investigación Biomédica

It has been demonstrated that eliminating mutated KRAS protein using PROTACs induces rapid tumour regression in mouse models of lung adenocarcinoma

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A multicentre study confirms the low incidence of HIV among PrEP users

by Fundació Clínic per a la Recerca Biomèdica

A Spanish multicentre study confirms that HIV infections among people using pre-exposure prophylaxis (PrEP) are uncommon and are mainly associated with interruptions or difficulties in adherence to pr...

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Identity & Chemical Purity of Polymeric Excipients

by Curapath

Polymeric excipients are key to advanced drug‑delivery systems, as their structure and impurity profile directly affect safety, stability, and in vivo performance. With rising regulatory expectation...

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Protein’s role in male reproductive ageing identified

by Universitat Autònoma de Barcelona (UAB)

A study by the UAB and the IJC demonstrates that SIRT7 is a key regulator of the quality of male germ cells and that the deficiency of this protein during ageing can lead to a functional decline in sp...

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Purified Omega-3 Treatment Reduces Cardiac Damage After a Heart Attack by Acting Directly on the Heart

by Hospital de la Santa Creu i Sant Pau

A type of omega-3 fatty acid found in oily fish, used as a medication to lower triglycerides, may directly protect the heart after a heart attack. A study led by the Research Institute of Sant Pau (IR...

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Targeted therapies improve efficacy in early-phase clinical trials driven by molecular patient selection

by VHIO

Researchers at VHIO have published an article in the journal European Journal of Cancer on the evolution of targeted therapies in early-phase clinical trials. The study shows a progressive improvement...

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Un método basado en inteligencia artificial reduce un 90% el tiempo para obtener resonancias magnéticas

by CSIC - Centro Superior de Investigaciones Científicas

El trabajo del Instituto de Neurociencias (CSIC-UMH) permitiría reducir de 40 minutos a menos de 10 el tiempo de la prueba diagnóstica, manteniendo un alto nivel de precisión

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Detección temprana de la neurodiversidad: entender para cuidar

by Universidad Politécnica de Madrid

No todos los niños y niñas se relacionan con el mundo de la misma manera, y entender esas diferencias a tiempo puede marcar una gran diferencia en su desarrollo. Con esta idea, la Universidad PolitÃ...

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Autorización de uso frente a autorización de medicamento en Terapias Avanzadas: diferencias clave desde la investigación clínica

by Sermes CRO

El escenario regulatorio de las Terapias Avanzadas es complejo. En él conviven autorizaciones de uso hospitalario con medicamentos plenamente aprobados por la EMA. Entender esta dualidad permite anti...

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Retention in Clinical Trials

by Pivotal

Clinical trials are the cornerstone of evidence-based medicine, yet a remarkable proportion of them fail not because the science is wrong, but because participants do not stay.

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A study identifies the endocannabinoid system as a potential therapeutic target in severe acute pancreatitis

by Hospital Universitari Germans Trias i Pujol

The study shows that circulating levels of the endocannabinoid 2-AG decrease in patients who later develop severe acute pancreatitis. This pattern was also observed in the experimental model used by t...

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Identifican una nueva estrategia que ayuda a reducir la metástasis del melanoma y a mejorar la inmunoterapia en ratones

by Centro Nacional de Biotecnología (CNB)

En modelos preclínicos, la inhibición de una molécula clave en las primeras fases de la metástasis del melanoma, reduce la propagación del tumor a otros órganos

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