Un estudio liderado por el Hospital público 12 de Octubre asocia el uso de antibióticos de amplio espectro con peores resultados clínicos en pacientes con mieloma múltiple

by Hospital Universitario 12 de Octubre

Han demostrado por primera vez que la administración de antibióticos de amplio espectro, antes de iniciar un tratamiento con anticuerpos biespecíficos —una forma avanzada de inmunoterapia—, se ...

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A new way to observe the release of proteins encapsulated in nanoparticles

by Institute for Advanced Chemistry of Catalonia (IQAC-CSIC)

Precision medicine aims to transport therapeutic agents, such as molecules, proteins or RNA, to the exact place where they need to act within the body. One of the most promising strategies is the use ...

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The left and right ventricles differ in their ability to withstand the effects of cardiac arrest

by Centro Nacional de Investigaciones Cardiovasculares - CNIC

The findings, published in Cardiovascular Research, show that the right ventricle has greater metabolic resilience than the left during cardiac arrest caused by ventricular fibrillation.

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Fat molecule inside cell nucleus shifts with cell division

by Centre for Genomic Regulation

invResearchers have shown that a type of fat molecule, long associated with signalling at the cell's outer membrane, also operates inside the nucleus on a schedule that matches the rhythm of cell divi...

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Promising results for a novel bispecific antibody

by VHIO

The HERIZON-GEA-01 open-label, phase 3 clinical trial was designed to compare first-line treatment with the bispecific antibody zanidatamab plus chemotherapy with or without PD‐1 monoclonal antibody...

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Opening the door to new therapeutic strategies in patients with bronchiectasis

by IMIM - Institut Hospital del Mar d'Investigacions Mèdiques

People diagnosed with bronchiectasis show loss of muscle mass early on and in mild and moderate stages of this respiratory disease. This is why it is so important to understand the molecular mechanism...

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Investigadores del ibs.GRANADA participan en un ensayo clínico que cambiará el manejo del déficit de hierro en el embarazo

by Instituto de Investigación Biosanitaria - Ibs Granada

El estudio, publicado en The Lancet Haematology, demuestra que tratar de forma precoz el déficit de hierro en mujeres embarazadas, incluso antes de que aparezca anemia, mejora la salud materna y feta...

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Hallada una proteína clave para la recuperación del corazón tras un ataque cardíaco

by Instituto de Biomedicina de Sevilla - IBIS

El estudio apunta a Orai1 como un regulador esencial para regenerar nuevos vasos sanguíneos necesarios para reparar el corazón después de un infarto.

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Un estudio preclínico abre la puerta a tratamientos personalizados de la hipertensión en hombres y mujeres

by INCLIVA

Este estudio muestra que la hipertensión arterial altera el funcionamiento de los vasos sanguíneos renales tanto en machos como en hembras, aunque no lo hace de la misma manera. En ambos casos se ob...

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KRAS degradation induces rapid lung cancer regression in preclinical mouse models

by IRB Barcelona - Instituto de Investigación Biomédica

It has been demonstrated that eliminating mutated KRAS protein using PROTACs induces rapid tumour regression in mouse models of lung adenocarcinoma

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A multicentre study confirms the low incidence of HIV among PrEP users

by Fundació Clínic per a la Recerca Biomèdica

A Spanish multicentre study confirms that HIV infections among people using pre-exposure prophylaxis (PrEP) are uncommon and are mainly associated with interruptions or difficulties in adherence to pr...

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Identity & Chemical Purity of Polymeric Excipients

by Curapath

Polymeric excipients are key to advanced drug‑delivery systems, as their structure and impurity profile directly affect safety, stability, and in vivo performance. With rising regulatory expectation...

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