The way our cells respond to oestrogen, the main female sex hormone, depends on how DNA is ‘supercoiled’

by CNIO - Centro Nacional de Investigaciones Oncológicas

This discovery reveals that the way DNA twists or 'supercoils' is key for cells to respond to oestrogens.

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Neutrophils are less aggressive at night, explaining why nighttime heart attacks cause less damage than daytime events

by Centro Nacional de Investigaciones Cardiovasculares - CNIC

A CNIC study reveals that neutrophils—a type of immune cell—are less aggressive at night, explaining why nighttime heart attacks are less severe than those occurring during the day

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VIOLET Pharmaceuticals, the new spin-off of the Hospital del Mar Research Institute Barcelona, increases the effectiveness of immunotherapies for metastatic cancer

by IMIM - Institut Hospital del Mar d'Investigacions Mèdiques

This spin-off of the Hospital del Mar Research Institute Barcelona seeks to make tumour cells visible by forcing them to overexpress the LCOR protein, which regulates tumour "visibility" by promoting ...

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Mini-cólones bioartificiales para ver nacer el cáncer de colon en el laboratorio

by Professional Newco

El artículo del Dr. Francisco Lorenzo, científico de la Universidad de Salamanca y del Centro de Investigación del Cáncer (CSIC-USAL), publicado en Nature Protocols detalla por primera vez cómo g...

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Results from IMMUNOMICS-VHIO platform’s first study demonstrate the efficacy of ultrasensitive liquid biopsy in predicting and monitoring immunotherapy response

by VHIO

Published today in Clinical Cancer Research, results from this project’s first study show that ultrasensitive circulating tumor DNA analysis can predict immunotherapy response in patients with advan...

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A new study shows targeted immunotherapy halves metastasis risk in high-risk early HER2+ breast cancer

by Fundació Clínic per a la Recerca Biomèdica

The international DESTINY-Breast05 trial, published in The New England Journal of Medicine, demonstrates that the antibody-drug conjugate trastuzumab deruxtecan (T-DXd) reduces by half the risk of inv...

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Implementation of UPLC‑MS/MS workflows in peptide therapeutics: from method development to regulatory submission

by AMSbiopharma

The integration of Ultra-High Performance Liquid Chromatography (UPLC) with tandem mass spectrometry has proven essential for accurate quantification and characterization. This technical advancement r...

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Un estudio revela que el cuerpo emplea sensores distintos para detectar el frío en la piel y en los órganos internos

by CSIC - Centro Superior de Investigaciones Científicas

Un equipo liderado por el IN-CSIC-UMH ha comprobado en modelos animales que los mecanismos moleculares de detección del frío no son uniformes en todo el cuerpo

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Investigadores del CIC abordan nuevas vías para profundizar en los mecanismos de acción de los fármacos contra el cáncer

by Professional Newco

El amplio mapa desarrollado de fármacos y genes diana, y el método innovador (denominado "farmaco-genómica") representan una herramienta prometedora para acelerar la identificación de nuevas diana...

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Demuestran el efecto neuroprotector del grafeno frente a los principales mecanismos celulares implicados en enfermedades como el párkinson

by Universidad de Málaga

La investigación, liderada por la Universidad de Málaga, revela que este material, en dosis bajas y en sus distintas formas reducidas, favorece la maduración neuronal y protege frente al estrés ox...

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A new study reveals the essential role of galectin-9 in immune system activation

by CIC bioGUNE

A new study published in PNAS uncovers the essential role of galectin-9 (gal9) in orchestrating how dendritic cells activate T cells, revealing a previously unknown mechanism that could inspire next-g...

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