Development of new p38 protein inhibitors with therapeutic potential for some heart diseases

by IRB Barcelona - Instituto de Investigación Biomédica

A research team from IRB Barcelona and the biotech Nostrum Biodiscovery has developed a new type of inhibitor that blocks only some of the functions of the p38 protein. The alternative pathway that th...

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First nanoscale direct observation of how glass transforms into liquid at increasing temperature

by Universitat Autònoma de Barcelona (UAB)

Researchers from the UAB and the ICN2 have developed a methodology that makes it possible for the first time to observe under the microscope, in real time, what happens when glass is heated and change...

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The role of oxidative stress in the progression of Alzheimer's disease is shown to affect only the cellular level

by IRB Lleida. Institut de Recerca Biomèdica

It has been has shown that the role of oxidative stress in the progression of Alzheimer's disease affects only at the cellular level and instead, damage in extracellular fluids, such as plasma and cer...

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LRP1-based immunotherapy would reduce remodeling of the cardiac extracellular matrix due to cholesterol accumulation

by Hospital de la Santa Creu i Sant Pau

It has been revealed that LRP1-based immunotherapy reduces cardiac extracellular matrix (ECM) remodeling induced by intracellular accumulation of esterified cholesterol in cardiomyocytes.

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New collaboration agreement with the ICR and Vivan Therapeutics to design new personalized treatments against cancer

by IDIBELL - Institut d’Investigació Biomèdica de Bellvitge

A collaboration has been signed between the Bellvitge Biomedical Research Institute (IDIBELL), the Institute of Cancer Research (ICR) in London, and Vivan Therapeutics to jointly develop molecules tha...

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An already approved drug could help eliminate resistance to the most effective treatment against metastatic breast cancer

by CNIO - Centro Nacional de Investigaciones Oncológicas

An international study with CNIO participation has discovered that RANK protein contributes to this resistance and that an already approved drug to treat osteoporosis blocks the protein

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Investigadores de INCLIVA estudian los posibles efectos adversos de la presencia de citomegalovirus (CMV) en la sangre de pacientes receptores de terapia CAR-T

by INCLIVA

Investigadores del Instituto de Investigación Sanitaria INCLIVA, del Hospital Clínico de València, han desarrollado un estudio para analizar y evitar los posibles efectos adversos derivados de la p...

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Orikine Bio closes €5.5m Series Seed Financing with Sabadell Asabys and AdBio

by Asabys Partners

Orikine Bio, a biotech company developing a novel proprietary platform for cytokine-based therapies for autoimmune and inflammatory diseases, announces today the successful closing of a €5.5m seed f...

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Mineralys Therapeutics Announces Expansion of Planned Phase 2 Trial of Lorundrostat Alone and in Combination with SGLT2 Inhibitor to Treat Patients with Chronic Kidney Disease (CKD)

by Ysios Capital

Mineralys Therapeutics today announced details of an expanded two-part Phase 2 clinical trial for lorundrostat as a potential therapy to treat patients with Stage 2 to 4 chronic kidney disease (CKD), ...

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Los astrocitos utilizan los ácidos grasos para mantener las capacidades cognitivas

by DiCYT - Agencia Iberoamericana para la Difusión de la Ciencia y la Tecnología

En su mayor parte los componentes primordiales de las grasas “van destinados a que la cadena respiratoria de la mitocondria de estas células cerebrales se organice para producir especies reactivas ...

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Researchers outline the mechanisms that control the conversion between fetal and adult intestinal stem cells

by IDIBELL - Institut d’Investigació Biomèdica de Bellvitge

Using different molecular approaches, they demonstrate the utility of organoid models to identify the factors that regulate cell fate and reveal that the transcription factors SMARCA4 and SMARCC1 prev...

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Una mutación en el gen DOCK11 explica un trastorno raro en la regulación del sistema inmunitario

by Fundació Sant Joan de Déu

​Investigadores del Institut de Recerca Sant Joan de Déu · Hospital Sant Joan de Déu Barcelona participan en un estudio internacional, publicado en la prestigiosa revista científica New England ...

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