La inhibición de la proteína inflamatoria IL-11 aumenta la esperanza de vida en ratones

by Revista Genética Médica

La inhibición de la proteína inflamatoria interleucina 11 (IL-11) mejora la salud y aumenta hasta un 25% la esperanza de vida en ratones.

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Identificación exhaustiva de variantes genéticas en el gen BAP1 y su implicación en el cáncer

by Revista Genética Médica

Investigadores del Instituto Sanger Wellcome han analizado el efecto de miles de variantes en el gen BAP1 para identificar aquellas que aumentan el riesgo a desarrollar varios tipos de cáncer. Las mÃ...

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Mechanisms of action of lithium in bipolar disorder and other neurological diseases reviewed

by Fundació Clínic per a la Recerca Biomèdica

Researchers at the Clínic-IDIBAPS have prepared a review article on the biology, mechanism of action, pharmacology and toxicology of lithium.

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Un antioxidante celular favorece el crecimiento de los tumores linfáticos y su resistencia terapéutica

by CSIC - Centro Superior de Investigaciones Científicas

Un estudio liderado por el CSIC identifica que el glutatión, uno de los antioxidantes más abundantes en las células, favorece la supervivencia de las células iniciadoras de los tumores linfáticos...

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Viral defence protein speeds up female stem cell production

by Centre for Genomic Regulation

​Researchers at the Centre for Genomic Regulation (CRG) have discovered a treatment which accelerates the production and quality of pluripotent stem cells in mice. This discovery that has the potent...

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HIF-2α inhibitor improves outcomes in patients with previously treated advanced clear cell renal carcinoma

by VHIO

Results of the phase III LITESPARK-005 clinical trial show that treatment with belzutifan versus everolimus significantly improves progression-free survival in patients with advanced clear cell renal ...

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The Epicardial Fat of Patients with Type 2 Diabetes Exerts Negative Effects on Cardiac Cells That Are Reversed in the Presence of ApoJ

by Hospital de la Santa Creu i Sant Pau

The cultured epicardial fat from T2DM patients secretes more atherogenic ceramide species and, in the case of T2DM with coronary disease, more saturated free fatty acids than that of non-diabetic pati...

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What we eat does change our cancer risk. CNIO researchers want to know why

by CNIO - Centro Nacional de Investigaciones Oncológicas

Regarding cancer prevention and food, the recommendation is to avoid obesity and alcohol, as well as eating plenty of vegetables and reducing red meat and processed food. However, on a molecular scale...

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'Detective’ Algorithm Predicts Best Drugs for Genetic Disorders and Cancer

by IRB Barcelona - Instituto de Investigación Biomédica

RTDetective is a new computational model which can predict which drugs will be most effective in treating diseases caused by premature stop codons, or ‘stop signs’ that appear in DNA and result in...

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Por qué el ejercicio físico estimula el deseo de mantenerse activo: revelan la relación molecular entre el músculo y el cerebro

by Centro Nacional de Investigaciones Cardiovasculares - CNIC

Los músculos activan la p38γ a causa del ejercicio y secretan una cantidad mayor de la proteína interleuquina 15 (IL-15), que tiene un efecto directo sobre la parte de la corteza cerebral que contr...

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Approved by EMA, novel oral AKT inhibitor in combination improves clinical outcomes and prolongs quality of life in patients with advanced HR+/HER2- breast cancer

by VHIO

The European Medicines Agency (EMA) recently approved the combination of novel AKT inhibitor capivasertib with fulvestrant for patients with hormone receptor (HR)-positive, HER2-negative advanced or m...

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A study shows how international travel affects the gut microbiota

by Instituto de Investigación e Innovación Parc Taulí

A diverse and resilient microbiota is key to good health, and understanding how travel affects it could help design better preventative strategies

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