Researchers identify a new gene inactivation mechanism that influences development and is related to disease

by IRB Barcelona - Instituto de Investigación Biomédica

Researchers at IRB Barcelona and the Institut Curie describe a new phenomenon of functional instability called “Illuminati”. Published in the scientific journal Development, this is an epigenetic ...

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A team from the UB and IBUB reveals the extraordinary plasticity of the glucocorticoid receptor

by Universitat de Barcelona

GR is a highly plastic protein with a highly versatile structure: its monomers (constituent molecules) are able to self-assemble in different ways to form dimers, tetramers and complexes with other pr...

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INCLIVA participa en un ensayo clínico internacional que comparará la eficacia de abemaciclib y terapia endocrina frente a la quimioterapia en cáncer de mama avanzado

by INCLIVA

El Instituto de Investigación Sanitaria INCLIVA participa en un ensayo clínico internacional, denominado ABIGAIL, que comparará la eficacia de abemaciclib en combinación con terapia endocrina (let...

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Vall d'Hebron leads a study that analyzes the current situation of Dent's disease in Europe

by Vall d’Hebron

The research has also allowed to describe new findings regarding the impact of age and genotype on the progression to chronic kidney disease in patients with Dent's disease

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Investigadores de INCLIVA, en colaboración con el Hospital General y el Hospital La Fe, muestran que el tratamiento con genisteína podría retrasar la aparición de demencia en pacientes con Alzheimer

by INCLIVA

El ensayo clínico GENIAL ha evaluado en humanos la eficacia de un suplemento con genisteína, un polifenol presente en la soja con efectos beneficiosos frente a enfermedades degenerativas

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Identifican una estrategia terapéutica efectiva contra un subtipo de melanoma que actualmente no tiene tratamiento

by Universitat Rovira i Virgili

Uno de los subtipos más comunes de melanoma es causado por mutaciones en NRAS, una proteína relacionada con la malignidad de las células que se halla alterado en un 25% de los casos. Su tratamiento...

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A biomarker in a blood test makes it possible to diagnose Alzheimer’s disease

by Fundació Clínic per a la Recerca Biomèdica

A study by the hospital Clínic Barcelona-IDIBAPS, published in the journal Neurology, confirms the usefulness of a blood-based biomarker to diagnose Alzheimer’s disease without the need for more in...

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Identifiquen dos biomarcadors en pacients amb esclerosi lateral amiotròfica (ELA)

by Hospital de la Santa Creu i Sant Pau

L;os pacientes con esclerosis lateral amiotrófica (ELA) presentan niveles anormalmente elevados de las proteínas NOD2 y Spp1, por lo que estas moléculas se postulan como nuevos biomarcadores en la ...

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A new atlas unveils which mutations are behind the noxious amyloid formation

by IBEC - Institut de Bioenginyeria de Catalunya

Researchers from the Institute for Bioengineering of Catalonia (IBEC) have developed the most complete atlas up to date with the genetic mutations that causes the formation of amyloid beta fibril, a p...

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CNIO researchers discover how to predict the efficacy of one of the most widely used drugs against breast cancer

by CNIO - Centro Nacional de Investigaciones Oncológicas

The CNIO group analyzed HER2-negative breast cancer samples from 130 patients treated with paclitaxel, one of the most widely used drugs against breast, ovarian, lung, bladder, prostate, melanoma, eso...

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Researchers uncover the mechanism of action of an important transcription factor

by IRB Barcelona - Instituto de Investigación Biomédica

Scientists at IRB Barcelona detail the DNA binding mechanism of FoxH1, a protein involved in embryonic development and in some tumour processes.

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The most common type 2 diabetes drug needs the action of a cellular-stress-response protein to make effect

by Universitat de Barcelona

Metformin, the most prescribed drug for treating diabetes mellitus, known as type 2 diabetes, requires the presence of the growth differentiation factor 15 (GDF15) —a protein whose expression increa...

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