Revelan claves sobre la heterogeneidad celular y su impacto en el cáncer

by Instituto de Biomedicina de Sevilla - IBIS

El estudio muestra cómo el tipo de célula que origina un linaje y una proteína clave del ciclo celular, determinan la proliferación lenta o rápida, un hallazgo relevante para entender la resisten...

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A new biomarker has been identified that helps predict cardiovascular risk in people with chronic kidney disease

by Universidad de Extremadura

It has been found that the combination of two proteins (FGF19 and β-Klotho), along with associated genetic variants, makes it possible to predict which patients with Chronic Kidney Disease have a hig...

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CNAG maps the most complete set of protein domains in human endogenous retroviruses

by Parc Científic de Barcelona

It has been analysed a vast dataset of 120,000 open reading frames (ORFs) derived from human endogenous retroviruses (HERVs) and identified 17,540 retroviral protein domains. The study paves the way f...

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Nuevos biomarcadores no invasivos para la detección y el seguimiento de la Distrofia Miotónica Tipo 1

by Biodonostia

Las personas con DM1 tuvieron niveles significativamente más altos de NFL (una proteína que se libera cuando los nervios se dañan) e IL-6 (una proteína que indica inflamación) que las personas sa...

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A therapeutic target that would curb the spread of coronaviruses has been identified

by UPF - Universitat Pompeu Fabra

It is an enzyme that is activated in human cells in response to stress due to infection and causes changes in the cellular machinery that favour the production and spread of coronaviruses.

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The key to attacking 'undruggable' proteins: IRB Barcelona reveals a breakthrough drug mechanism

by IRB Barcelona - Instituto de Investigación Biomédica

Published in Science Advances, the study shows that the drug does not act on the protein in isolation, but instead takes advantage of the moment when they briefly group together into small complexes (...

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A New Design Strategy in Nanomedicine Improves Antitumor Efficacy While Reducing Drug Dose

by Hospital de la Santa Creu i Sant Pau

the research team developed protein-based nanomedicines capable of self-assembling into multivalent nanoparticles and selectively targeting tumor cells that overexpress the CXCR4 receptor. This recept...

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Research, core topic understanding obesity and transforming its treatment

by Universidad de Navarra

On World Obesity Day, scientists from the Institute of Nutrition and Health at the University of Navarra present research aimed at advancing toward more personalized treatment on a portal

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Cancer has a unique nuclear metabolic fingerprint

by Centre for Genomic Regulation

More than two hundred metabolic enzymes, many of which are normally tasked with producing energy in the mitochondria, are also found sitting directly on top of human DNA, according to a study publishe...

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La URV desarrolla una nueva herramienta para analizar más de 250.000 estructuras de proteínas

by Universitat Rovira i Virgili

Este nuevo software facilita la clasificación automática de las estructuras del Protein Data Bank, una de las bases de datos de referencia internacional que hace posible el diseño computacional de ...

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The importance of transferrin in rapid Helicobacter pylori testing

by OPERON

The simultaneous detection of H.pylori antigen and transferrin in stool samples using a rapid test represents a significant advance in non-invasive diagnosis, as it allows both the infection caused by...

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The University of Extremadura identifies a therapeutic target in the study of breast cancer

by Universidad de Extremadura

A team of researchers from the University of Extremadura has discovered that the Notch1 signaling pathway regulates two calcium channels, Orai1 and Orai3, differently depending on the breast cancer su...

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