A new study reveals that prostate cancer alters the function of the cells that support blood vessels

by CIC bioGUNE

The new study shows that pericytes do not disappear, instead, they are reprogrammed. This dysfunction is regulated by a cytokine (a secreted protein) called TGF-β, which acts as a messenger between t...

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A light-based modulation tool for brain plasticity opens promising avenues for treating Huntington’s disease

by Universitat de Barcelona

Researchers at the University of Barcelona used an innovative optogenetic tool to show that astrocytes, a type of brain cell traditionally considered to play a supporting role, also influence this pla...

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Efficacy of a drug demonstrated in preclinical models to halt rhabdomyosarcoma growth

by IMIM - Institut Hospital del Mar d'Investigacions Mèdiques

​The research team led by the Institut de Recerca Joan de Déu (IRSJD) and the Hospital del Mar Research Institute has, for the first time, demonstrated the efficacy of a drug in animal models devel...

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Un equipo resucita proteínas ancestrales para descifrar la evolución celular de la vida en la Tierra

by Centro Nacional de Biotecnología (CNB)

Se trata de la primera reconstrucción estructural de proteínas ancestrales multiméricas, es decir, aquellas capaces de ensamblarse para generar una función biológica nueva

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Plant hormone allows lifelong control of proteins in living animal

by Centre for Genomic Regulation

Researchers have found a way to control protein levels inside different tissues of a whole, living animal for the first time. The method lets scientists dial protein levels up or down with great preci...

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Un estudio identifica el papel clave del colesterol en la migración de las células del sistema inmunológico

by Centro Nacional de Biotecnología (CNB)

Investigadores del CNB-CSIC han descubierto que los niveles de colesterol en la membrana celular afectan a la capacidad de las células inmunitarias para migrar a los tejidos donde son necesarias

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A Study Reveals How Hippocampal Synapses Adjust Their Proteins to Specialize Their Function

by Hospital de la Santa Creu i Sant Pau

A research team led by Dr. Àlex Bayés, Head of the Molecular Physiology of the Synapse Group at the Institut de Recerca Sant Pau (IR Sant Pau), has achieved what for decades had been an elusive goal...

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VIOLET Pharmaceuticals, the new spin-off of the Hospital del Mar Research Institute Barcelona, increases the effectiveness of immunotherapies for metastatic cancer

by IMIM - Institut Hospital del Mar d'Investigacions Mèdiques

This spin-off of the Hospital del Mar Research Institute Barcelona seeks to make tumour cells visible by forcing them to overexpress the LCOR protein, which regulates tumour "visibility" by promoting ...

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Lecanemab, donanemab y los inicios de una nueva era en el tratamiento del Alzheimer

by Fundación Pasqual Maragall

En este artículo echamos un vistazo a las novedades sobre el fármaco lecanemab, el primero aprobado por la vía tradicional por algunas agencias reguladoras del medicamento tras décadas de la últi...

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Estudian la relación entre el intestino y el hígado y su posible papel clave en la progresión de enfermedades hepáticas

by Universidad de Málaga

Este trabajo sugiere que algunos mecanismos inmunológicos y de disfunción intestinal podrían ser compartidos entre diferentes tipos de daño hepático, como el inducido por fármacos, la hepatitis ...

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Implementation of UPLC‑MS/MS workflows in peptide therapeutics: from method development to regulatory submission

by AMSbiopharma

The integration of Ultra-High Performance Liquid Chromatography (UPLC) with tandem mass spectrometry has proven essential for accurate quantification and characterization. This technical advancement r...

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