A key genetic safeguard works differently across tissues and individuals

by IRB Barcelona - Instituto de Investigación Biomédica

The efficiency of the Nonsense-Mediated mRNA Decay (NMD) pathway, a genetic quality control mechanism, differs across human tissues and individuals.

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Integrated DNA Technologies and Hamilton Partner to Automate Customizable NGS Workflows and Accelerate Biomarker Discovery

by Integrated DNA Technologies

Strategic partnership provides complete automation-friendly solution for IDT NGS workflows on Hamilton’s liquid handling systems and enables user choice for solid tumor, heme comprehensive genomic p...

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La evolución ‘frena’ las repeticiones aminoacídicas ‘tóxicas’ en proteínas con un patrón común en 30 especies

by Universidad Pablo de Olavide, de Sevilla

Un estudio llevado a cabo en el CABD revela que el genoma coloca estratégicamente codones CAA para limitar la expansión peligrosa de tramos de glutamina, con los peces como gran excepción

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Generative AI more efficient than nature at designing genome-editing proteins

by Centre for Genomic Regulation

It has been designed and experimentally validated new synthetic proteins that can edit the human genome more efficiently than proteins provided by nature that will be of great use in improving the cur...

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Descubren un nuevo gen causante de una miopatía congénita

by CIBERER - Centro de Investigación Biomédica en Red de Enfermedades Raras

Mediante técnicas de secuenciación masiva de nueva generación, los autores identificaron en los pacientes diferentes mutaciones en el gen CACNB1, que hasta ahora no había sido asociado a ninguna e...

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Study identifies the best breeding strategy for more productive wheat varieties

by Universitat de Barcelona

José Luis Araus, professor at the University of Barcelona’s Faculty of Biology and member of Agrotecnio — CERCA centre in agrotechnology — participated in a study showing that wheat varieties p...

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El metabolismo del colesterol ayuda a predecir la viabilidad de los injertos en trasplante hepático

by CIBEREHD-Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

La acumulación de colesterol en el hígado y la mayor expresión de los genes reguladores SREBF2 y HMGCR permiten anticipar complicaciones tempranas, pérdida del injerto e incluso mortalidad, tras u...

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An Overview of Transfection: Methods, Challenges and Applications

by Canvax Biotech

Transfection remains a cornerstone technique in molecular biology, enabling discoveries that shape our understanding of life at the genetic level. While various methods and reagents exist, only a few ...

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Researchers at IRBLleida and IDIBELL identify key molecules in the progression of endometrial cancer

by IRB Lleida. Institut de Recerca Biomèdica

This is a key advance in designing new treatments that can address diseases prevalent among women, such as endometrial cancer and endometriosis

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Descubren nuevos genes de predisposición al síndrome de distrés respiratorio agudo asociado a infecciones graves

by Professional Newco

La variación genética en el gen identificado en este estudio (el gen codificante de la 3-Hydroxy-3-Methylglutaryl-CoA (HMG-CoA) reductasa) se ha asociado previamente con cómo responden algunas pers...

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Deciphering the mechanisms of genome size evolution

by Universitat de Barcelona

The discovery, published in the journal Molecular Biology and Evolution, reveals for the first time how an animal species managed to reduce its genome by almost half during oceanic island colonization...

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